| pubmed-article:8342683 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8342683 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:8342683 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:8342683 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:8342683 | lifeskim:mentions | umls-concept:C0001349 | lld:lifeskim |
| pubmed-article:8342683 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:8342683 | pubmed:issue | 1 Pt 2 | lld:pubmed |
| pubmed-article:8342683 | pubmed:dateCreated | 1993-8-27 | lld:pubmed |
| pubmed-article:8342683 | pubmed:abstractText | Nine untrained men (22-29 yr) performed 45 min of downhill running (16% incline, 70% of maximum heart rate). Needle biopsies of the vastus lateralis were performed before, 45 min after, and 5 days after exercise. Immunohistochemical staining of muscle cross sections revealed a 135% increase in muscle interleukin-1 beta (IL-1 beta) immediately after and a 250% increase (P < 0.03) 5 days after exercise. Using a rating scale (0-3) for the presence of neutrophils, light microscopic examination showed a significant accumulation of neutrophils in muscle biopsies taken 45 min after and 5 days after exercise [before: 0.5 +/- 0.2, 45 min after: 1.5 +/- 0.3 (P < 0.01), and 5 days after: 1.2 +/- 0.2 (P < 0.04)]. In addition, electron microscopic analysis showed an increase in the percentage of damaged Z-bands relative to total Z-bands [before: 4.8 +/- 3.5%, 45 min after: 32.5 +/- 8.6% (P < 0.05), and 5 days after: 14.1 +/- 3.2%]. Neutrophil accumulation was positively correlated to intracellular Z-band damage (rho = 0.66, P < 0.001). Immunohistochemical staining for IL-1 beta was related to neutrophil accumulation in muscle (rho = 0.38, P < 0.06) and to plasma creatine kinase levels (rho = 0.416, P < 0.04). These data indicate that after eccentric exercise ultrastructural damage to skeletal muscle is associated with neutrophil infiltration and muscle IL-1 beta accumulation. | lld:pubmed |
| pubmed-article:8342683 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8342683 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8342683 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8342683 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8342683 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8342683 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8342683 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8342683 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8342683 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:CannonJ GJG | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:EvansW JWJ | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:FiataroneM... | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:DingWW | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:FieldingR ARA | lld:pubmed |
| pubmed-article:8342683 | pubmed:author | pubmed-author:ManfrediT JTJ | lld:pubmed |
| pubmed-article:8342683 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8342683 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:8342683 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8342683 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8342683 | pubmed:pagination | R166-72 | lld:pubmed |
| pubmed-article:8342683 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:meshHeading | pubmed-meshheading:8342683-... | lld:pubmed |
| pubmed-article:8342683 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8342683 | pubmed:articleTitle | Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle. | lld:pubmed |
| pubmed-article:8342683 | pubmed:affiliation | United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111. | lld:pubmed |
| pubmed-article:8342683 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8342683 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8342683 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8342683 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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