pubmed-article:8338143 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8338143 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:8338143 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
pubmed-article:8338143 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
pubmed-article:8338143 | lifeskim:mentions | umls-concept:C0013725 | lld:lifeskim |
pubmed-article:8338143 | lifeskim:mentions | umls-concept:C0596233 | lld:lifeskim |
pubmed-article:8338143 | pubmed:issue | 1 Pt 1 | lld:pubmed |
pubmed-article:8338143 | pubmed:dateCreated | 1993-8-26 | lld:pubmed |
pubmed-article:8338143 | pubmed:abstractText | The role of arachidonic acid (AA) and its metabolites in vasopressin (AVP)-induced calcium mobilization in A7r5 aortic smooth muscle cells was explored by intracellular calcium monitoring, [14C]AA labeling, and high-performance liquid chromatography (HPLC) techniques. In fura 2-loaded A7r5 cells, AA potentiated AVP-stimulated increase in intracellular free Ca2+ ([Ca2+]i). The cyclooxygenase inhibitor indomethacin reduced both the AA- and AVP-induced influx of extracellular Ca2+. AVP-induced [Ca2+]i transients were not altered by lipoxygenase inhibitors but were reduced in a dose-dependent fashion by ketoconazole, an inhibitor of cytochrome P-450 monooxygenases. Among several epoxygenase metabolites of AA tested, 5,6-epoxyeicosatrienoic acid potentiated AVP-induced [Ca2+]i transients. Reverse-phase HPLC analysis of lipid extracts from A7r5 cells prelabeled with [14C]AA isolated a radioactive peak that did not coelute with established products of cyclooxygenase-, lipoxygenase-, or cytochrome P-450-catalyzed oxidations of AA. This peak was significantly increased after AVP stimulation and was completely blocked by preincubation with ketoconazole. Thus the stimulation of V1-vascular AVP receptors of A7r5 cells triggers several cytoplasmic signaling pathways involving AA metabolite formation through the cyclooxygenase and epoxygenase pathways. | lld:pubmed |
pubmed-article:8338143 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:language | eng | lld:pubmed |
pubmed-article:8338143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8338143 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8338143 | pubmed:month | Jul | lld:pubmed |
pubmed-article:8338143 | pubmed:issn | 0002-9513 | lld:pubmed |
pubmed-article:8338143 | pubmed:author | pubmed-author:ThibonnierMM | lld:pubmed |
pubmed-article:8338143 | pubmed:author | pubmed-author:KoopD RDR | lld:pubmed |
pubmed-article:8338143 | pubmed:author | pubmed-author:SimonsonM SMS | lld:pubmed |
pubmed-article:8338143 | pubmed:author | pubmed-author:LaethemC LCL | lld:pubmed |
pubmed-article:8338143 | pubmed:author | pubmed-author:BayerA LAL | lld:pubmed |
pubmed-article:8338143 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8338143 | pubmed:volume | 265 | lld:pubmed |
pubmed-article:8338143 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8338143 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8338143 | pubmed:pagination | E108-14 | lld:pubmed |
pubmed-article:8338143 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:8338143 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8338143 | pubmed:articleTitle | Role of eicosanoids in vasopressin-induced calcium mobilization in A7r5 vascular smooth muscle cells. | lld:pubmed |
pubmed-article:8338143 | pubmed:affiliation | Department of Medicine, University Hospitals of Cleveland, Ohio. | lld:pubmed |
pubmed-article:8338143 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8338143 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |