| pubmed-article:8333665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8333665 | lifeskim:mentions | umls-concept:C0039483 | lld:lifeskim |
| pubmed-article:8333665 | lifeskim:mentions | umls-concept:C1956391 | lld:lifeskim |
| pubmed-article:8333665 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:8333665 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:8333665 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8333665 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8333665 | pubmed:dateCreated | 1993-8-17 | lld:pubmed |
| pubmed-article:8333665 | pubmed:abstractText | Fourteen monoclonal antibodies were used to immunohistochemically label 22 temporal artery biopsy specimens taken from patients with temporal arteritis before treatment (n = 10), after 1.3 days of corticotherapy (n = 6) and after 12-30 days of steroids (n = 6). Histological sections from untreated patients revealed an inflammatory infiltrate comprised of approximately equal proportions of macrophages and T lymphocytes; the majority of the latter belonged to the CD4+ subset (the CD4+/CD8+ ratio varied from 2/1 to 4/1, depending upon the biopsy). These cells expressed high levels of HLA DR and low levels of interleukin-2 (IL2) receptors. A few B lymphocytes and plasmocytes were seen, mainly in the adventitia. Antigen-presenting cells (APC) were always found in the damaged media and natural killer cells (few in number) were sometimes present. Some macrophages were positively immunolabeled for IL6. A short, 1-to-3-day course of corticosteroids did not appreciably modify the lesions: cells remained highly activated, APC were seen in half the biopsies and IL6 immunolabeling persisted. The findings were essentially the same in treated but poorly controlled patients. Biopsies from 2 patients in clinical and biological remission revealed the persistence of an active immunological process. These observations indicate that the immunological process is poorly controlled by corticosteroid therapy. | lld:pubmed |
| pubmed-article:8333665 | pubmed:language | fre | lld:pubmed |
| pubmed-article:8333665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8333665 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8333665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8333665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8333665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8333665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8333665 | pubmed:issn | 0003-410X | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:VidalEE | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:CatanzanoGG | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:LiozonFF | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:GalanaudPP | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:CrevonM CMC | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:EmilieDD | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:LiozonEE | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:LavignacCC | lld:pubmed |
| pubmed-article:8333665 | pubmed:author | pubmed-author:BordessouleDD | lld:pubmed |
| pubmed-article:8333665 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8333665 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:8333665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8333665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8333665 | pubmed:pagination | 85-91 | lld:pubmed |
| pubmed-article:8333665 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:meshHeading | pubmed-meshheading:8333665-... | lld:pubmed |
| pubmed-article:8333665 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8333665 | pubmed:articleTitle | [Immunohistochemical study of lesions of temporal arteritis in Horton's disease]. | lld:pubmed |
| pubmed-article:8333665 | pubmed:affiliation | Service de Médecine Interne A, CHRU de Limoges. | lld:pubmed |
| pubmed-article:8333665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8333665 | pubmed:publicationType | English Abstract | lld:pubmed |
