| pubmed-article:8321196 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C0085218 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1567709 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C2698932 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1512666 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:8321196 | lifeskim:mentions | umls-concept:C0585064 | lld:lifeskim |
| pubmed-article:8321196 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8321196 | pubmed:dateCreated | 1993-7-30 | lld:pubmed |
| pubmed-article:8321196 | pubmed:abstractText | To probe the factors controlling immunoglobulin heavy-chain gene rearrangement, we analyzed Abelson virus-transformed pre-B-cell lines that fail to undergo VH-to-DJH joining at an appreciable frequency. Despite this feature, some of these cell lines (rechi) rearrange an extrachromosomal recombination substrate at levels normal for transformed pre-B cells. Others (reclo) rearrange these substrates at levels characteristic of nonlymphoid hematopoietic cells. The DJH rearrangements from a representative rechi cell line were aberrant, suggesting that these cells probably fail to complete heavy-chain gene assembly because some of the necessary cis-acting signals are missing. In contrast, both DJH rearrangements from a reclo cell line appeared normal in structure, indicating that trans-acting factors necessary for recombination might be missing. Introduction of the RAG-1 and RAG-2 genes, genes encoding two such factors, failed to confer a rechi phenotype to these cells. However, fusion of the reclo cells to a rechi cell line generated a high frequency of rechi hybrids. In addition, most of the hybrids rearranged the endogenous kappa light-chain locus. Neither the rechi phenotype nor kappa-chain rearrangement correlated with levels of RAG-1 and RAG-2 expression in all of the hybrids. Thus, both gene transfer and cell fusion experiments indicate that RAG-1 and RAG-2 are not sufficient to activate immunoglobulin gene recombination in at least some pre-B-cell lines. In addition, the fusion experiments suggest that two gene products in addition to RAG-1 and RAG-2 may be required for kappa-gene rearrangement. | lld:pubmed |
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| pubmed-article:8321196 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8321196 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8321196 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8321196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8321196 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8321196 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8321196 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8321196 | pubmed:author | pubmed-author:WangL CLC | lld:pubmed |
| pubmed-article:8321196 | pubmed:author | pubmed-author:RosenbergNN | lld:pubmed |
| pubmed-article:8321196 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8321196 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8321196 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8321196 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8321196 | pubmed:pagination | 3890-9 | lld:pubmed |
| pubmed-article:8321196 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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