| pubmed-article:8315381 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C0597722 | lld:lifeskim |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8315381 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8315381 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8315381 | pubmed:dateCreated | 1993-7-23 | lld:pubmed |
| pubmed-article:8315381 | pubmed:abstractText | The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations. | lld:pubmed |
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| pubmed-article:8315381 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8315381 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8315381 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8315381 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8315381 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:FinkelmanF... | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:GrabsteinK... | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:NamenA EAE | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:AlpertA RAR | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:WaldschmidtT... | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:MorrisseyP... | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:HessB WBW | lld:pubmed |
| pubmed-article:8315381 | pubmed:author | pubmed-author:BoianiN ENE | lld:pubmed |
| pubmed-article:8315381 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8315381 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8315381 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:8315381 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8315381 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8315381 | pubmed:pagination | 257-64 | lld:pubmed |
| pubmed-article:8315381 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8315381 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8315381 | pubmed:articleTitle | Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. | lld:pubmed |
| pubmed-article:8315381 | pubmed:affiliation | Immunex Research and Development Corporation, Seattle, Washington 98101. | lld:pubmed |
| pubmed-article:8315381 | pubmed:publicationType | Journal Article | lld:pubmed |
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