| pubmed-article:8312472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C0033216 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8312472 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:8312472 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8312472 | pubmed:dateCreated | 1994-3-23 | lld:pubmed |
| pubmed-article:8312472 | pubmed:abstractText | We have investigated the action of procainamide on batrachotoxin (BTX)-activated sodium channels from bovine heart and rat skeletal muscle. When applied to the intracellular side, procainamide induced rapid, open-channel block. We estimated rate constants using amplitude distribution analysis (Yellen, G. 1984. J. Gen. Physiol. 84:157). Membrane depolarization increased the blocking rate and slowed unblock. The rate constants were similar in both magnitude and voltage dependence for cardiac and skeletal muscle channels. Qualitatively, this block resembled the fast open-channel block by lidocaine (Zamponi, G. W., D. D. Doyle, and R. J. French. 1993. Biophys. J. 65:80), but procainamide was about sevenfold less potent. Molecular modeling suggests that the difference in potency between procainamide and lidocaine might arise from the relative orientation of their aromatic rings, or from differences in the structure of the aryl-amine link. For the cardiac channels, procainamide reduced the frequency of transitions to a long-lived closed state which shows features characteristic of inactivation (Zamponi, G. W., D. D. Doyle, and R. J. French. 1993. Biophys J. 65:91). Mean durations of kinetically identified closed states were not affected. The degree of fast block and of inhibition of the slow closures were correlated. Internally applied QX-314, a lidocaine derivative and also a fast blocker, produced a similar effect. Thus, drug binding to the fast blocking site appears to inhibit inactivation in BTX-activated cardiac channels. | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8312472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8312472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8312472 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8312472 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:8312472 | pubmed:author | pubmed-author:SukVV | lld:pubmed |
| pubmed-article:8312472 | pubmed:author | pubmed-author:FrenchR JRJ | lld:pubmed |
| pubmed-article:8312472 | pubmed:author | pubmed-author:CoddingP WPW | lld:pubmed |
| pubmed-article:8312472 | pubmed:author | pubmed-author:ZamponiG WGW | lld:pubmed |
| pubmed-article:8312472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8312472 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:8312472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8312472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8312472 | pubmed:pagination | 2324-34 | lld:pubmed |
| pubmed-article:8312472 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:meshHeading | pubmed-meshheading:8312472-... | lld:pubmed |
| pubmed-article:8312472 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8312472 | pubmed:articleTitle | Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation. | lld:pubmed |
| pubmed-article:8312472 | pubmed:affiliation | Department of Medical Physiology, University of Calgary, Alberta, Canada. | lld:pubmed |
| pubmed-article:8312472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8312472 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8312472 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8312472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8312472 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8312472 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8312472 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8312472 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8312472 | lld:pubmed |
