| pubmed-article:8286055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0013343 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0026383 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0025552 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:8286055 | lifeskim:mentions | umls-concept:C0053697 | lld:lifeskim |
| pubmed-article:8286055 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8286055 | pubmed:dateCreated | 1994-2-22 | lld:pubmed |
| pubmed-article:8286055 | pubmed:abstractText | Cyclic ribodiguanylic acid, c-(GpGp), is the endogenous effector regulator of cellulose synthase. Its three dimensional structure from two different crystal forms (tetragonal and trigonal) has been determined by x-ray diffraction analysis at 1 A resolution. Both structures were solved by direct methods and refined by block-matrix least squares refinement to R-factors of 0.112 (tetragonal) and 0.119 (trigonal). In both crystal forms, two independent c-(GpGp) molecules associate with each other to form a self-intercalated dimer. All four c-(GpGp) molecules have very similar backbone conformation. The riboses are in the C3'-endo pucker with pseudorotation angles ranging from -7.2 degrees to 16.5 degrees and the bases have anti glycosyl chi angles (-175.5 degrees to 179.7 degrees). In the tetragonal form, a hydrated cobalt ion is found to coordinate to two N7 atoms of adjacent guanines, forcing these two guanines to destack with a large dihedral angle (33 degrees). This metal coordination mechanism has been noted previously in other Pt- or Co-GMP complexes and may be relevant to the binding of the anticancer drug cisplatin to a GpG sequence in DNA. A model of the adduct between cisplatin and a d(CAATGGATTG) duplex has been constructed in which the induced bending of the DNA helix at the Pt crosslinking site is 33 degrees, consistent with earlier electrophoretic analyses. Moreover, c-(GpGp) exhibits unusual spectral properties not seen in other cyclic dinucleotides. It interacts with planar organic intercalator molecules in ways similar to double helical DNA. We propose a cage-like model consisting of a tetrameric c-(GpGp) aggregate in which a large cavity (host molecule) is generated to afford a binding site for certain planar intercalators (guests molecules). The aggregate likely uses a hydrogen bonding scheme the same as that found in the G-quartet molecules, e.g., telomere DNA. The conformation of c-(GpGp) also suggests that certain nearest-neighbor intercalators may be synthesized on the basis of its unique molecular framework. Modeling studies have been carried out to test this hypothesis. | lld:pubmed |
| pubmed-article:8286055 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8286055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8286055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8286055 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8286055 | pubmed:issn | 0739-1102 | lld:pubmed |
| pubmed-article:8286055 | pubmed:author | pubmed-author:RobinsonHH | lld:pubmed |
| pubmed-article:8286055 | pubmed:author | pubmed-author:WangA HAH | lld:pubmed |
| pubmed-article:8286055 | pubmed:author | pubmed-author:GaoY GYG | lld:pubmed |
| pubmed-article:8286055 | pubmed:author | pubmed-author:OldsB ABA | lld:pubmed |
| pubmed-article:8286055 | pubmed:author | pubmed-author:GuanYY | lld:pubmed |
| pubmed-article:8286055 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8286055 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:8286055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8286055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8286055 | pubmed:pagination | 253-76 | lld:pubmed |
| pubmed-article:8286055 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8286055 | pubmed:meshHeading | pubmed-meshheading:8286055-... | lld:pubmed |
| pubmed-article:8286055 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8286055 | pubmed:articleTitle | Molecular structure of cyclic diguanylic acid at 1 A resolution of two crystal forms: self-association, interactions with metal ion/planar dyes and modeling studies. | lld:pubmed |
| pubmed-article:8286055 | pubmed:affiliation | Division of Biophysics, University of Illinois at Urbana-Champaign 61801. | lld:pubmed |
| pubmed-article:8286055 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8286055 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8286055 | lld:pubmed |
