| pubmed-article:8280117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8280117 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:8280117 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:8280117 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:8280117 | lifeskim:mentions | umls-concept:C1100714 | lld:lifeskim |
| pubmed-article:8280117 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8280117 | pubmed:dateCreated | 1994-2-10 | lld:pubmed |
| pubmed-article:8280117 | pubmed:abstractText | The origin of amyloid beta (A beta) deposited in brain and cerebral blood vessels of patients with Alzheimer's Disease (AD) is not known. In this study, we tested whether soluble A beta (sA beta) can cross the blood-brain barrier (BBB). An in vivo vascular brain perfusion model and capillary depletion technique in guinea-pigs were used to determine cerebral capillary sequestration and blood-brain transport of a synthetic peptide identical with residues 1-40 (SP-40) of A beta. A saturable, specific binding of SP-40 has been demonstrated at the luminal side of the BBB, with the Kd of 25 +/- 2 nM, and Bmax of 188 +/- 11 fmol/min/g of isolated microvessels. A specific transcellular BBB transport of SP-40 into brain parenchyma exhibited the Km of 49 +/- 10 nM, and Vmax of 111 +/- 19 fmol/min/g of capillary depleted brain. We concluded that the BBB has the capability to control the cerebrovascular sequestration and blood-to-brain transport of circulating sA beta. Hence, sA beta can contribute to both cerebrovascular and parenchymal amyloid formation. | lld:pubmed |
| pubmed-article:8280117 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8280117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8280117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8280117 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8280117 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:WeissM HMH | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:FrangioneBB | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:McCombJ GJG | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:GhisoJJ | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:ZlokovicB VBV | lld:pubmed |
| pubmed-article:8280117 | pubmed:author | pubmed-author:MackicJ BJB | lld:pubmed |
| pubmed-article:8280117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8280117 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:8280117 | pubmed:volume | 197 | lld:pubmed |
| pubmed-article:8280117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8280117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8280117 | pubmed:pagination | 1034-40 | lld:pubmed |
| pubmed-article:8280117 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8280117 | pubmed:meshHeading | pubmed-meshheading:8280117-... | lld:pubmed |
| pubmed-article:8280117 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8280117 | pubmed:articleTitle | Blood-brain barrier transport of circulating Alzheimer's amyloid beta. | lld:pubmed |
| pubmed-article:8280117 | pubmed:affiliation | Department of Neurological Surgery, Childrens Hospital, Los Angeles, USC School of Medicine 90033. | lld:pubmed |
| pubmed-article:8280117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8280117 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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