Linked Life Data

8280071

Source:http://linkedlifedata.com/resource/pubmed/id/8280071

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8280071rdf:typepubmed:Citationlld:pubmed
pubmed-article:8280071lifeskim:mentionsumls-concept:C0028623lld:lifeskim
pubmed-article:8280071lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:8280071lifeskim:mentionsumls-concept:C0205419lld:lifeskim
pubmed-article:8280071lifeskim:mentionsumls-concept:C1519751lld:lifeskim
pubmed-article:8280071lifeskim:mentionsumls-concept:C1156200lld:lifeskim
pubmed-article:8280071lifeskim:mentionsumls-concept:C0205360lld:lifeskim
pubmed-article:8280071pubmed:dateCreated1994-2-7lld:pubmed
pubmed-article:8280071pubmed:abstractTextThe properties of the nucleosomes of a salt-soluble, transcriptionally active gene-enriched fraction of chicken erythrocyte chromatin were evaluated by hydroxyapatite dissociation chromatography. We have demonstrated previously that the salt-soluble, transcriptionally active gene-enriched polynucleosomes are enriched in dynamically acetylated and ubiquitinated histones, and in an atypical U-shaped nucleosome that possessed about 20% less protein than a typical nucleosome. Further, newly synthesized histones H2A and H2B exchange preferentially with the nucleosomal histones H2A and H2B of this salt-soluble chromatin fraction. Analysis of the histones eluting from the hydroxyapatite-bound chromatin demonstrated that hyperacetylated and ubiquitinated (u), including multi-ubiquitinated, H2A-H2B.1 dimers dissociated at lower concentrations of NaCl than unmodified dimers or dimers with histone variants H2A.Z and/or H2B.2. Cross-linking studies revealed that at least 50% of uH2B.1 was paired with uH2A. uH2A-uH2B.1 dimers dissociated at lower NaCl concentrations than H2A-uH2B.1 dimers. Hyperacetylated histone (H3-H4)2 tetramers also eluted at lower concentrations of NaCl than unmodified tetramers. Our results support the idea that acetylation and ubiquitination of histones H2A and H2B.1 increase the lability of H2A-H2B.1 dimers in transcriptionally active nucleosomes. In contrast, our observations suggest that histone variants H2A.Z and H2B.2. stabilize the association of the H2A-H2B dimer in nucleosomes. The elevated lability of the H2A-H2B dimer may facilitate processes such as the exchange of these dimers with newly synthesized histones, the elongation process of transcription and transcription factor binding.lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:languageenglld:pubmed
pubmed-article:8280071pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:citationSubsetIMlld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8280071pubmed:statusMEDLINElld:pubmed
pubmed-article:8280071pubmed:monthDeclld:pubmed
pubmed-article:8280071pubmed:issn0264-6021lld:pubmed
pubmed-article:8280071pubmed:authorpubmed-author:DavidJ SJSlld:pubmed
pubmed-article:8280071pubmed:authorpubmed-author:LUCClld:pubmed
pubmed-article:8280071pubmed:authorpubmed-author:HendzelM JMJlld:pubmed
pubmed-article:8280071pubmed:authorpubmed-author:DelcuveG PGPlld:pubmed
pubmed-article:8280071pubmed:authorpubmed-author:NagarajaSSlld:pubmed
pubmed-article:8280071pubmed:issnTypePrintlld:pubmed
pubmed-article:8280071pubmed:day15lld:pubmed
pubmed-article:8280071pubmed:volume296 ( Pt 3)lld:pubmed
pubmed-article:8280071pubmed:ownerNLMlld:pubmed
pubmed-article:8280071pubmed:authorsCompleteYlld:pubmed
pubmed-article:8280071pubmed:pagination737-44lld:pubmed
pubmed-article:8280071pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:meshHeadingpubmed-meshheading:8280071-...lld:pubmed
pubmed-article:8280071pubmed:year1993lld:pubmed
pubmed-article:8280071pubmed:articleTitleEffects of histone acetylation, ubiquitination and variants on nucleosome stability.lld:pubmed
pubmed-article:8280071pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.lld:pubmed
pubmed-article:8280071pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8280071pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:396425entrezgene:pubmedpubmed-article:8280071lld:entrezgene
entrez-gene:417956entrezgene:pubmedpubmed-article:8280071lld:entrezgene
entrez-gene:426361entrezgene:pubmedpubmed-article:8280071lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:8280071lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:8280071lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:8280071lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8280071lld:pubmed
More...