| pubmed-article:8263505 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0085112 | lld:lifeskim |
| pubmed-article:8263505 | lifeskim:mentions | umls-concept:C0286079 | lld:lifeskim |
| pubmed-article:8263505 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8263505 | pubmed:dateCreated | 1994-1-26 | lld:pubmed |
| pubmed-article:8263505 | pubmed:abstractText | Severe combined immune deficient (SCID) mice inoculated intravenously with vaccinia virus (VV) became sick within 6-8 days and died 10-12 days after infection. Tail lesions developed and the number depended on the virus inoculum. Age-matched immunocompetent NMRI mice similarly infected also developed tail lesions but did not become sick. When the infected SCID mice were treated with the acyclic nucleoside phosphonate HPMPC [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine], either for 5 consecutive days starting on the day of infection or for 5 consecutive days starting on day 2, 4, or 6 post infection, or as a single dose at 7 days or 1 day before infection, VV-associated death was significantly delayed. VV-infected SCID mice that received two doses of 20 mg/kg of HPMPC every week survived the infection for about 130 days. The period during which the mice remained disease-free following HPMPC treatment correlated with the absence of detectable virus in their organs. The VV/SCID mouse model employed here may be useful for determining whether (attenuated) recombinant VV (carrying HIV genes) may have detrimental effects in the immunodeficient host. HPMPC may be considered as a drug candidate for the treatment and prophylaxis of such complications. | lld:pubmed |
| pubmed-article:8263505 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8263505 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8263505 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8263505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8263505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8263505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8263505 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8263505 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8263505 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:8263505 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:8263505 | pubmed:author | pubmed-author:NeytsJJ | lld:pubmed |
| pubmed-article:8263505 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8263505 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:8263505 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8263505 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8263505 | pubmed:pagination | 242-6 | lld:pubmed |
| pubmed-article:8263505 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8263505 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8263505 | pubmed:articleTitle | Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice. | lld:pubmed |
| pubmed-article:8263505 | pubmed:affiliation | Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:8263505 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8263505 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19090 | entrezgene:pubmed | pubmed-article:8263505 | lld:entrezgene |
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