pubmed-article:8256503 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0036126 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0007292 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C1519878 | lld:lifeskim |
pubmed-article:8256503 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:8256503 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:8256503 | pubmed:dateCreated | 1994-1-12 | lld:pubmed |
pubmed-article:8256503 | pubmed:abstractText | A peptide comprising residues glu293 to ser334 from the principal neutralization determinant (V3 loop) of the envelope of human immunodeficiency virus type 1 (HIV1 LAVBRU isolate) has been inserted within internal permissive sites of either LamB or MalE, two envelope proteins from Escherichia coli K12. The MalE hybrid protein (MalE133-V3 loop) was stably expressed in the periplasm of Escherichia coli K12, and the V3 loop peptide was detectable on the surface of the native protein by an anti-gp160 monoclonal antibody (mAb 110-A). The disulfide bridge between the two cysteines of the loop was formed. In contrast, genetic coupling to the outer membrane protein LamB did not allow the expression of a stable hybrid protein, and major proteolytic cleavage products of the LamB153-V3 loop were detected by mAb 110-A. The two plasmid-encoded hybrid genes were transferred to an aroA mutant of Salmonella typhimurium. Constitutive expression of the MalE133-V3 loop had no detectable effect on cell growth and on the survival in vivo of the recipient strain. The LamB153-V3 loop was not stably expressed in Salmonella, either in vitro or in vivo. Live recombinant salmonellas expressing MalE-V3 and LamB-V3 loop hybrids were used to immunize mice. The MalE-V3 loop hybrid induced anti-HIV1 envelope antibodies detectable by Western blot and ELISA, while the anti-HIV1 envelope antibodies induced by the LamB-V3 loop hybrid were only detectable by Western blot. In addition, purified MalE-V3 loop hybrid protein was able to stimulate in vitro and induce in vivo a V3 loop-specific T-cell proliferative response. | lld:pubmed |
pubmed-article:8256503 | pubmed:language | eng | lld:pubmed |
pubmed-article:8256503 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8256503 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8256503 | pubmed:month | Sep | lld:pubmed |
pubmed-article:8256503 | pubmed:issn | 0264-410X | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:HofnungMM | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:O'CallaghanDD | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:LeclercCC | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:MartineauPP | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:CharbitAA | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:RoncoJJ | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:MichelVV | lld:pubmed |
pubmed-article:8256503 | pubmed:author | pubmed-author:Lo-ManRR | lld:pubmed |
pubmed-article:8256503 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8256503 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:8256503 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8256503 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8256503 | pubmed:pagination | 1221-8 | lld:pubmed |
pubmed-article:8256503 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:8256503 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8256503 | pubmed:articleTitle | Expression and immunogenicity of the V3 loop from the envelope of human immunodeficiency virus type 1 in an attenuated aroA strain of Salmonella typhimurium upon genetic coupling to two Escherichia coli carrier proteins. | lld:pubmed |
pubmed-article:8256503 | pubmed:affiliation | Programmation Moleculaire et Toxicologie Génétique (CNRS URA 1444), Institut Pasteur, Paris, France. | lld:pubmed |
pubmed-article:8256503 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8256503 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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