| pubmed-article:8194879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0494165 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0016360 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0009429 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:8194879 | lifeskim:mentions | umls-concept:C0076612 | lld:lifeskim |
| pubmed-article:8194879 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8194879 | pubmed:dateCreated | 1994-6-27 | lld:pubmed |
| pubmed-article:8194879 | pubmed:abstractText | We studied the effect of combined chemo-immunotherapy, 5-FU followed by thymosin alpha 1 (T alpha 1) and interleukin-2 (IL-2) at low doses, on liver metastases from colorectal cancer, induced by splenic injection of DHD/K12 cells (1,2-dimethylhydrazine-induced colon adenocarcinoma) in syngeneic BDIX rats. The presence of liver metastases was checked by laparotomy 14 days after tumor-cell injection. Evaluable rats were assigned randomly to 5 experimental groups designated as control, 5-FU, IL-2, 5-FU/IL-2 and 5-FU/T alpha 1/IL-2. 5-FU was administered i.v. as a continuous infusion for 7 days by an osmotic device implanted surgically. T alpha 1 and IL-2 were administered for 4 days and repeated after 11 days. Combined chemo-immunotherapy was shown both to significantly reduce the growth of liver metastases and to prevent extra-hepatic spread. 5-FU/T alpha 1/IL-2 also improved survival rate. Combined immunotherapy after 5-FU restored NK activity of the peripheral-blood-mononuclear-cell (PBMC) in tumor and/or 5-FU immunodepressed rats and enhanced PBMC cytotoxic activity against the DHD/K12 autologous cell line. This model was devised to mimic the clinical situation of unresectable liver metastases. | lld:pubmed |
| pubmed-article:8194879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8194879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8194879 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8194879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8194879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8194879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8194879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8194879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8194879 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8194879 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:GaraciEE | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:SpazianiEE | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:RasiGG | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:TremiterraSS | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:SilecchiaGG | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:Sinibaldi-Val... | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:PierimarchiPP | lld:pubmed |
| pubmed-article:8194879 | pubmed:author | pubmed-author:SiviliaMM | lld:pubmed |
| pubmed-article:8194879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8194879 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8194879 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:8194879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8194879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8194879 | pubmed:pagination | 701-5 | lld:pubmed |
| pubmed-article:8194879 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:meshHeading | pubmed-meshheading:8194879-... | lld:pubmed |
| pubmed-article:8194879 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8194879 | pubmed:articleTitle | Anti-tumor effect of combined treatment with thymosin alpha 1 and interleukin-2 after 5-fluorouracil in liver metastases from colorectal cancer in rats. | lld:pubmed |
| pubmed-article:8194879 | pubmed:affiliation | Istituto di Medicina Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy. | lld:pubmed |
| pubmed-article:8194879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8194879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8194879 | lld:pubmed |
