| pubmed-article:8186957 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8186957 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8186957 | pubmed:dateCreated | 1994-6-22 | lld:pubmed |
| pubmed-article:8186957 | pubmed:abstractText | Enhanced expression of beta-adrenoceptor densities on peripheral blood mononuclear cells (PBMCs) in progressive multiple sclerosis patients has been observed in a number of independent studies. A link between increased number of beta-adrenoceptors and inflammatory disease has been further indicated by studies in rheumatoid arthritis and relapsing-remitting multiple sclerosis patients. In a serial monthly assessment of relapsing-remitting multiple sclerosis patients, we have demonstrated that increased beta-adrenoceptors on PBMCs correlate with the expression of high affinity interleukin-2 receptors (IL-2Rs) and disease activity as determined by clinical and MRI findings. Magnetic resonance imaging activity was strongly correlated with IL-2R expression and it appears to be a sensitive marker of PBMC immunoactivation in multiple sclerosis. In vitro studies showed that beta-agonist stimulation of PBMCs reduces the IL-2R expression and suppresses cell proliferation following mitogenic stimulation. This observation may indicate a recovery role for the enhanced beta-adrenoceptor expression in multiple sclerosis. However, its therapeutic importance remains to be tested by appropriate trials using either beta-agonists or agents activating the second messenger system, c-AMP, in lymphocytes. | lld:pubmed |
| pubmed-article:8186957 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8186957 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8186957 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8186957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8186957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8186957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8186957 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8186957 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8186957 | pubmed:issn | 0006-8950 | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:ThompsonA JAJ | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:CuznerM LML | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:KiddDD | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:WoodroofeM... | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:KendallB EBE | lld:pubmed |
| pubmed-article:8186957 | pubmed:author | pubmed-author:ZoukosYY | lld:pubmed |
| pubmed-article:8186957 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8186957 | pubmed:volume | 117 ( Pt 2) | lld:pubmed |
| pubmed-article:8186957 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8186957 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8186957 | pubmed:pagination | 307-15 | lld:pubmed |
| pubmed-article:8186957 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:meshHeading | pubmed-meshheading:8186957-... | lld:pubmed |
| pubmed-article:8186957 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8186957 | pubmed:articleTitle | Increased expression of high affinity IL-2 receptors and beta-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis. | lld:pubmed |
| pubmed-article:8186957 | pubmed:affiliation | Multiple Sclerosis Laboratory, National Hospital for Neurology and Neurosurgery, London, UK. | lld:pubmed |
| pubmed-article:8186957 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8186957 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8186957 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8186957 | lld:pubmed |
