| pubmed-article:8167929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0683140 | lld:lifeskim |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0336562 | lld:lifeskim |
| pubmed-article:8167929 | lifeskim:mentions | umls-concept:C0442087 | lld:lifeskim |
| pubmed-article:8167929 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8167929 | pubmed:dateCreated | 1994-5-27 | lld:pubmed |
| pubmed-article:8167929 | pubmed:abstractText | Metabolic activity of a gel-entrapment, hollow fiber, bioartificial liver was evaluated in vitro and during extracorporeal hemoperfusion in an anhepatic rabbit model. The bioartificial liver contained either 100 million rat hepatocytes (n = 12), fibroblasts (n = 3), or no cells (n = 7) during hemoperfusion of anhepatic rabbits. Eight other anhepatic rabbits were studied without hemoperfusion as anhepatic controls, and three sham rabbits served as normal controls. Albumin production rates (mean +/- SEM) were similar during in vitro (17.0 +/- 2.8 micrograms/h) and extracorporeal (18.0 +/- 4.0 micrograms/h) application of the hepatocyte bioartificial liver. Exogenous glucose requirements were reduced (p < 0.01) and euglycemia was prolonged (p < 0.001) in anhepatic rabbits treated with the hepatocyte bioartificial liver. The maximum rate of glucose production by the hepatocyte bioartificial liver ranged from 50-80 micrograms/h. Plasma concentrations of aromatic amino acids, proline, alanine, and ammonia were normalized in anhepatic rabbits during hepatocyte hemoperfusion. Gel-entrapped hepatocytes in the bioartifical liver performed sulfation and glucuronidation of 4-methylumbelliferone. P450 activity was demonstrated during both in vitro and extracorporeal application of the BAL device by the formation of 3-hydroxy-lidocaine, the major metabolite of lidocaine biotransformation by gel-entrapped rat hepatocytes. In summary, a gel-entrapment, bioartificial liver performed multiple hepatocyte-specific functions without adverse side effects during extracorporeal application in an anhepatic, small animal model. With its potential for short term support of acute liver failure, scale-up of the current bioartificial liver device is indicated for further investigations in large animal, preclinical trials. | lld:pubmed |
| pubmed-article:8167929 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8167929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8167929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8167929 | pubmed:issn | 0963-6897 | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:CerraF BFB | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:PayneW DWD | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:HuW SWS | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:ShirabeKK | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:MannH JHJ | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:CrottyP LPL | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:PeshwaM VMV | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:RemmelR PRP | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:NybergS LSL | lld:pubmed |
| pubmed-article:8167929 | pubmed:author | pubmed-author:SielaffT DTD | lld:pubmed |
| pubmed-article:8167929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8167929 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:8167929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8167929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8167929 | pubmed:pagination | 441-52 | lld:pubmed |
| pubmed-article:8167929 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8167929 | pubmed:articleTitle | Extracorporeal application of a gel-entrapment, bioartificial liver: demonstration of drug metabolism and other biochemical functions. | lld:pubmed |
| pubmed-article:8167929 | pubmed:affiliation | Department of Surgery, University of Minnesota, Minneapolis 55455. | lld:pubmed |
| pubmed-article:8167929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8167929 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8167929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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