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| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C1705274 | lld:lifeskim |
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| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C1705273 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C2827501 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8157609 | lifeskim:mentions | umls-concept:C0075804 | lld:lifeskim |
| pubmed-article:8157609 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8157609 | pubmed:dateCreated | 1994-5-13 | lld:pubmed |
| pubmed-article:8157609 | pubmed:abstractText | The glp operons of Escherichia coli are negatively controlled by the glp repressor. Comparison of the repressor-binding affinities for consensus and altered consensus operators in vivo showed that all base substitutions at positions 3, 4, 5, and 8 from the center of the palindromic operator caused a striking decrease in repressor binding. Substitutions at other positions had a severe to no effect on repressor binding, depending on the base substitution. The results obtained indicate that the repressor binds with highest affinity to operators with the half-site WATKYTCGWW, where W is A or T, K is G or T, and Y is C or T. Strong cooperative binding of the repressor to tandem operators was demonstrated in vivo. Cooperativity was maximal when two 20-bp operators were directly repeated or when 2 bp separated the two operators. Cooperativity decreased with the deletion of 2 bp or the addition of 4 bp between the individual operators. Cooperativity was eliminated with a 6-bp insertion between the operators. | lld:pubmed |
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| pubmed-article:8157609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8157609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8157609 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8157609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8157609 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8157609 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:OhWW | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:LarsonT JTJ | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:ThrasherK SKS | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:ZhaoNN | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:TrybulDD | lld:pubmed |
| pubmed-article:8157609 | pubmed:author | pubmed-author:KingsburyT... | lld:pubmed |
| pubmed-article:8157609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8157609 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:8157609 | pubmed:geneSymbol | glp | lld:pubmed |
| pubmed-article:8157609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8157609 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8157609 | pubmed:pagination | 2393-7 | lld:pubmed |
| pubmed-article:8157609 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8157609 | pubmed:meshHeading | pubmed-meshheading:8157609-... | lld:pubmed |
| pubmed-article:8157609 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8157609 | pubmed:articleTitle | Characterization of the interaction of the glp repressor of Escherichia coli K-12 with single and tandem glp operator variants. | lld:pubmed |
| pubmed-article:8157609 | pubmed:affiliation | Department of Biochemistry and Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308. | lld:pubmed |
| pubmed-article:8157609 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8157609 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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