| pubmed-article:8139559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0332255 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1418576 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1418577 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1423080 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1423613 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1424600 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:8139559 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8139559 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8139559 | pubmed:dateCreated | 1994-4-28 | lld:pubmed |
| pubmed-article:8139559 | pubmed:abstractText | Phosphatidylinositol (PI) 3-kinase is a heterodimeric enzyme of 85-kDa (p85) and 110-kDa (p110) subunits implicated in mitogenic signal transduction by virtue of its activation in cells transformed by diverse viral oncoproteins and treated with various growth factors. We have identified a domain in p110 that mediates association with p85 in vitro and in intact cells. A glutathione S-transferase fusion protein containing the N-terminal 171 amino-acids of p110 beta bound to free p85 in cell lysates. This fusion protein also bound directly to p85 immobilized on nitrocellulose filters. An epitope-tagged fragment containing amino acids 31 to 150 of p110 beta associated with p85 upon expression in intact cells. Expression of either an N-terminal fragment of p110 beta or the p85 inter-SH2 domain, which mediates association with p110, reduced the association of endogenous PI 3-kinase activity with the activated platelet-derived growth factor receptor in intact cells. Hence, these defined regions of p85 and p110 mediate the interaction between the two subunits of PI 3-kinase. | lld:pubmed |
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| pubmed-article:8139559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8139559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139559 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8139559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8139559 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8139559 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8139559 | pubmed:author | pubmed-author:SchlessingerJ... | lld:pubmed |
| pubmed-article:8139559 | pubmed:author | pubmed-author:LI | lld:pubmed |
| pubmed-article:8139559 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8139559 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8139559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8139559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8139559 | pubmed:pagination | 2577-83 | lld:pubmed |
| pubmed-article:8139559 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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