| pubmed-article:8139536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0035544 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0030943 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0058985 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C0079160 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C1549781 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:8139536 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:8139536 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8139536 | pubmed:dateCreated | 1994-4-28 | lld:pubmed |
| pubmed-article:8139536 | pubmed:abstractText | eIF-4B is a eukaryotic translation initiation factor that is required for the binding of ribosomes to mRNAs and the stimulation of the helicase activity of eIF-4A. It is an RNA-binding protein that contains a ribonucleoprotein consensus sequence (RNP-CS)/RNA recognition motif (RRM). We examined the effects of deletions and point mutations on the ability of eIF-4B to bind a random RNA, to cooperate with eIF-4A in RNA binding, and to enhance the helicase activity of eIF-4A. We report here that the RNP-CS/RRM alone is not sufficient for eIF-4B binding to RNA and that an RNA-binding region, located between amino acids 367 and 423, is the major contributor to RNA binding. Deletions which remove this region abolish the ability of eIF-4B to cooperate with eIF-4A in RNA binding and the ability to stimulate the helicase activity of eIF-4A. Point mutations in the RNP-CS/RRM had no effect on the ability of eIF-4B to cooperate with eIF-4A in RNA binding but significantly reduced the stimulation of eIF-4A helicase activity. Our results indicate that the carboxy-terminal RNA-binding region of eIF-4B is essential for eIF-4B function and is distinct from the RNP-CS/RRM. | lld:pubmed |
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| pubmed-article:8139536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8139536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139536 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8139536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8139536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8139536 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8139536 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8139536 | pubmed:author | pubmed-author:HersheyJ WJW | lld:pubmed |
| pubmed-article:8139536 | pubmed:author | pubmed-author:SonenbergNN | lld:pubmed |
| pubmed-article:8139536 | pubmed:author | pubmed-author:PauseAA | lld:pubmed |
| pubmed-article:8139536 | pubmed:author | pubmed-author:MéthotNN | lld:pubmed |
| pubmed-article:8139536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8139536 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8139536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8139536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8139536 | pubmed:pagination | 2307-16 | lld:pubmed |
| pubmed-article:8139536 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
