| pubmed-article:8136118 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0205101 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8136118 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:8136118 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8136118 | pubmed:dateCreated | 1994-4-26 | lld:pubmed |
| pubmed-article:8136118 | pubmed:abstractText | Incubation of mammalian cells in medium containing low K+ is often associated with an increase in Na,K-ATPase activity and content. In the present studies, we investigated the effect of low K+ on the regulation of Na,K-ATPase alpha 1 and beta 1 gene expression in primary cultures of neonatal rat cardiac myocytes. Northern blot hybridization analysis indicated that exposure of cardiocytes to a medium containing 0.3 mmol/L K+ for 72 h resulted in 1.8- and 3.3-fold increases in the abundance of alpha 1 and beta 1 mRNAs, respectively, compared with control cells exposed to 5.4 mmol/L K+. To investigate the molecular mechanism of the low K effect on beta 1 mRNA content, we constructed chimeric genes with a full-length and deleted portion of the 5' end of the rat beta 1 gene linked to the firefly luciferase gene. Transient transfection experiments using these constructs indicated that beta 1 gene sequences between -102 and +151 base pairs (bp) are required for low K(+)-induced trans-activation of reporter gene expression. Taken together, these results indicate that low K+ induction of beta 1 mRNA abundance in neonatal rat cardiac myocytes is mediated by regulatory DNA sequences in close proximity to the site of transcription initiation of the beta 1 gene. | lld:pubmed |
| pubmed-article:8136118 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8136118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8136118 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8136118 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8136118 | pubmed:issn | 0895-7061 | lld:pubmed |
| pubmed-article:8136118 | pubmed:author | pubmed-author:LinKK | lld:pubmed |
| pubmed-article:8136118 | pubmed:author | pubmed-author:GickGG | lld:pubmed |
| pubmed-article:8136118 | pubmed:author | pubmed-author:QiuSS | lld:pubmed |
| pubmed-article:8136118 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8136118 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8136118 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8136118 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8136118 | pubmed:pagination | 96-9 | lld:pubmed |
| pubmed-article:8136118 | pubmed:dateRevised | 2009-2-24 | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:meshHeading | pubmed-meshheading:8136118-... | lld:pubmed |
| pubmed-article:8136118 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8136118 | pubmed:articleTitle | Low external K+ regulates Na,K-ATPase alpha 1 and beta 1 gene expression in rat cardiac myocytes. | lld:pubmed |
| pubmed-article:8136118 | pubmed:affiliation | Department of Biochemistry, State University of New York Health Science Center at Brooklyn 11203. | lld:pubmed |
| pubmed-article:8136118 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8136118 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8136118 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8136118 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8136118 | lld:pubmed |
