| pubmed-article:8110195 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C0376448 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C0039654 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:8110195 | lifeskim:mentions | umls-concept:C0069795 | lld:lifeskim |
| pubmed-article:8110195 | pubmed:dateCreated | 1994-3-23 | lld:pubmed |
| pubmed-article:8110195 | pubmed:abstractText | Phenylarsine oxide (PAO), an inhibitor of tyrosine phosphatases, has been found to inhibit the early elevation in cytosolic Ca2+ concentration ([Ca2+]i), related to the CD3 activation pathway in Jurkat T cells. This inhibition was dose-dependent, consistent with previously reported effects of PAO on tyrosine phosphatases, and reversed by dimercaptopropanol. By contrast, okadaic acid, an inhibitor of serine/threonine phosphatases, had no effect on CD3-induced Ca2+ flux. PAO was compared with phorbol 12-myristate 13-acetate (PMA), which caused a similar, although less potent, inhibition as previously described. The two reagents produced additive inhibition of the CD3-induced [Ca2+]i rise, but did not affect thapsigargin- or ionomycin-driven Ca2+ flux in Jurkat cells. PAO and PMA prevented cells from complete depletion of intracellular Ca2+ stores by an anti-CD3 monoclonal antibody (mAb) and restored, at least partially, the ionomycin-sensitive pool, when added after anti-CD3 mAb. Moreover, the CD3-induced inhibition of phosphatidylserine synthesis, due to depletion of internal Ca2+ stores, is reversed by PAO and PMA. Anti-phosphotyrosine immunoblot analysis show that these effects cannot be accounted for by an inhibition of CD3-induced tyrosine phosphorylations. We propose that PAO and, to a lesser extent, PMA allow the refilling of internal compartments by Ca2+, which consequently abrogates a capacitative entry of external Ca2+. | lld:pubmed |
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| pubmed-article:8110195 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8110195 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8110195 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8110195 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8110195 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8110195 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8110195 | pubmed:author | pubmed-author:AusselCC | lld:pubmed |
| pubmed-article:8110195 | pubmed:author | pubmed-author:BernardAA | lld:pubmed |
| pubmed-article:8110195 | pubmed:author | pubmed-author:BreittmayerJ... | lld:pubmed |
| pubmed-article:8110195 | pubmed:author | pubmed-author:DeckertMM | lld:pubmed |
| pubmed-article:8110195 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8110195 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8110195 | pubmed:volume | 297 ( Pt 3) | lld:pubmed |
| pubmed-article:8110195 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8110195 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8110195 | pubmed:pagination | 567-72 | lld:pubmed |
| pubmed-article:8110195 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8110195 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8110195 | pubmed:articleTitle | Phenylarsine oxide and phorbol myristate acetate inhibit the CD3-induced rise of cytosolic Ca2+ in Jurkat cells by refilling internal Ca2+ stores. | lld:pubmed |
| pubmed-article:8110195 | pubmed:affiliation | INSERM U343, Faculté de Médecine, Nice, France. | lld:pubmed |
| pubmed-article:8110195 | pubmed:publicationType | Journal Article | lld:pubmed |
