| pubmed-article:8108419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:8108419 | lifeskim:mentions | umls-concept:C2347338 | lld:lifeskim |
| pubmed-article:8108419 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8108419 | pubmed:dateCreated | 1994-3-22 | lld:pubmed |
| pubmed-article:8108419 | pubmed:abstractText | To explore the role of bcl-2 in T-cell development, a bcl-2 transgene was introduced into mice expressing a T-cell receptor (TCR) transgene encoding reactivity for the mouse male antigen HY presented by the H-2Db class I antigen of the major histocompatibility complex (MHC). Normal thymic development is contingent on the ability of immature thymocytes to interact with self-MHC molecules presented by thymic stroma (positive selection). Thus, thymocyte numbers are low in female anti-HY TCR transgenic mice with a nonselecting (H-2Dd) background. Expression of bcl-2 inhibited the death of nonselectable thymocytes since, strikingly, female H-2Dd bcl-2/TCR transgenic mice developed normal numbers of CD4+CD8+ thymocytes, although these did not mature further into functional T cells. Hence, TCR-MHC interaction may induce positive selection through two signals, one which saves cells from death by increasing Bcl-2 synthesis and another which promotes maturation. Male H-2Db anti-HY TCR transgenic mice normally have a very small thymus, due to deletion of the self-reactive T cells. Expression of bcl-2 reduced the efficiency of deletion, since bcl-2/TCR transgenic male mice accumulated 4- to 6-fold more thymocytes than did TCR transgenic male littermates. Anti-HY TCR-expressing cells were also more numerous in the peripheral lymphoid tissues, but these cells expressed abnormally low levels of CD8 co-receptor and were not responsive to the HY antigen. Thus, although bcl-2 expression hampers the deletion of immature self-reactive cells in the thymus, self-tolerance is maintained. | lld:pubmed |
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| pubmed-article:8108419 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8108419 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8108419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8108419 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8108419 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8108419 | pubmed:author | pubmed-author:von BoehmerHH | lld:pubmed |
| pubmed-article:8108419 | pubmed:author | pubmed-author:CorySS | lld:pubmed |
| pubmed-article:8108419 | pubmed:author | pubmed-author:HarrisA WAW | lld:pubmed |
| pubmed-article:8108419 | pubmed:author | pubmed-author:StrasserAA | lld:pubmed |
| pubmed-article:8108419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8108419 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8108419 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8108419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8108419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8108419 | pubmed:pagination | 1376-80 | lld:pubmed |
| pubmed-article:8108419 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8108419 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8108419 | pubmed:articleTitle | Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. | lld:pubmed |
| pubmed-article:8108419 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:8108419 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8108419 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8108419 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8108419 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12043 | entrezgene:pubmed | pubmed-article:8108419 | lld:entrezgene |
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