| pubmed-article:810194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C0002792 | lld:lifeskim |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:810194 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:810194 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:810194 | pubmed:dateCreated | 1976-1-14 | lld:pubmed |
| pubmed-article:810194 | pubmed:abstractText | Passive lung anaphylaxis (PLA) was investigated in rats sensitized by the intravenous injection of high titre reaginic antiserum prepared in rats. 2 The effect of various pharmacological antagonists on anaphylactic bronchoconstriction in vivo were examined. An antihistamine (mepyramine), a kallikrein inactivator (aprotinin) or a prostaglandin synthesis inhibitor (aspirin) did not inhibit PLA, whereas an anti-5-hydroxytryptamine agent (methysergide) and an anti-slow reacting substance-A agent (FPL 55712) significantly reduced the response. 3 Isolated perfused lungs taken from sensitized rats released, on challenge with the sensitizing antigen, histamine, 5-hydroxytryptamine, slow reacting substance of anaphylaxis (SRS-A) and prostaglandins, but no rabbit aorta contracting substance (RCS). 4 Disodium cromoglycate inhibited both anaphylactic bronchoconstriction in vivo and the anaphylactic release of mediators in vitro. Inhibition in vivo was dose-related. 5 Mediators from the intestine, the primary shock organ of anaphylaxis in the rat, did not contribute to the lung response. 6 Vagal reflex pathways were found not to be important in PLA in vivo. 7 The relationship between the mediators released following antigen challenge of passively sensitized rat lung in vitro and passive lung anaphylaxis in vivo is discussed. | lld:pubmed |
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| pubmed-article:810194 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:810194 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:810194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:810194 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:810194 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:810194 | pubmed:author | pubmed-author:FarmerJ BJB | lld:pubmed |
| pubmed-article:810194 | pubmed:author | pubmed-author:WoodsA MAM | lld:pubmed |
| pubmed-article:810194 | pubmed:author | pubmed-author:RichardsI MIM | lld:pubmed |
| pubmed-article:810194 | pubmed:author | pubmed-author:SheardPP | lld:pubmed |
| pubmed-article:810194 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:810194 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:810194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:810194 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:810194 | pubmed:pagination | 57-64 | lld:pubmed |
| pubmed-article:810194 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:810194 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:810194 | pubmed:articleTitle | Mediators of passive lung anaphylaxis in the rat. | lld:pubmed |
| pubmed-article:810194 | pubmed:publicationType | Journal Article | lld:pubmed |
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