| pubmed-article:8098345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C0079773 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C1523873 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C1367475 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C0205345 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8098345 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8098345 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8098345 | pubmed:dateCreated | 1993-6-15 | lld:pubmed |
| pubmed-article:8098345 | pubmed:abstractText | Antigen-dependent activation of T cells occurs through the T-cell antigen-receptor complex (TCR/CD3). Antigen-independent T-cell activation may occur through the surface molecules CDw60, CD2, and CD28. We wished to determine whether these antigen-independent T-cell-activation pathways could be involved in proliferation of leukemic T cells from patients with cutaneous T-cell lymphoma (CTCL). Whereas CDw60 was only expressed on 28% +/- 7% (mean +/- SEM) of blood T cells obtained from healthy control subjects (n = 4), CDw60 was expressed on 94% +/- 3% of blood T cells obtained from patients with CTCL (n = 4). Dual color immunofluorescence microscopy of the T-cell infiltrate in involved skin of these patients demonstrated that almost 100% of the T cells expressed CDw60. Not only did T cells in the patients with CTCL express CDw60, but triggering of the T cells with anti-CDw60 resulted in enhanced proliferation relative to anti-TCR/CD3 and mitogenic lectins. Other antigen-independent pathways also appeared highly active in the T cells from patients with CTCL because enhanced proliferation relative to anti-TCR/CD3 or mitogenic lectins was found when anti-CD2 or anti-CD28 plus phorbol ester was used as stimulant. Despite the brisk proliferation induced by anti-CDw60, anti-CD2, or anti-CD28, T cells from the patients did not produce detectable amounts of gamma-interferon. The inability to produce gamma-interferon correlates with our finding of absent (n = 3) or weak (n = 1) intercellular adhesion molecule-1 expression in the lesional keratinocytes in these patients. In conclusion, T cells of patients with CTCL demonstrate elevated expression of a T-cell-independent signaling molecule CDw60 and respond to antigen-independent activating signals. | lld:pubmed |
| pubmed-article:8098345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8098345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8098345 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8098345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8098345 | pubmed:month | May | lld:pubmed |
| pubmed-article:8098345 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:ThomsenKK | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:HansenE RER | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:RossC WCW | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:OTAM IMI | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:LarsenJ KJK | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:CooperK DKD | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:HoV CVC | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:VejlsgaardG... | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:BaadsgaardOO | lld:pubmed |
| pubmed-article:8098345 | pubmed:author | pubmed-author:HeidenheimMM | lld:pubmed |
| pubmed-article:8098345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8098345 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:8098345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8098345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8098345 | pubmed:pagination | 667-73 | lld:pubmed |
| pubmed-article:8098345 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8098345 | pubmed:meshHeading | pubmed-meshheading:8098345-... | lld:pubmed |
| pubmed-article:8098345 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8098345 | pubmed:articleTitle | Leukemic T cells from patients with cutaneous T-cell lymphoma demonstrate enhanced activation through CDw60, CD2, and CD28 relative to activation through the T-cell antigen receptor complex. | lld:pubmed |
| pubmed-article:8098345 | pubmed:affiliation | Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:8098345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8098345 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8098345 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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