| pubmed-article:8081851 | pubmed:abstractText | To assess the role of the cyclic amide moiety in indolocarbazole and bis-indole protein kinase C inhibitors, five amides in these series were synthesized in which the amide group is acyclic. These new compounds have no inhibitory effect on protein kinase C, indicating that the rigid cyclic structure of the amide group is compulsory for biological activity. | lld:pubmed |
