| pubmed-article:8077655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C1512631 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C1150527 | lld:lifeskim |
| pubmed-article:8077655 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8077655 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8077655 | pubmed:dateCreated | 1994-10-5 | lld:pubmed |
| pubmed-article:8077655 | pubmed:abstractText | Ig receptor (IgR) on the surface of B cells mediates the Ag-specific stimulatory signal for B cell proliferation and differentiation. In immature B cells, the stimulatory signal causes an inhibitory effect which is believed to be a key phenomenon in B cell tolerance or B cell anergy. Here, we studied the molecular mechanism of the inhibitory response of the IgR-mediated signal transduction that results in the programmed cell death of immature B cells. To analyze the downstream molecules of the IgR-mediated signal transduction, we prepared a mAb against a 160-kDa membrane protein (p160) that can coprecipitate the kinase molecule(s) acting on serine, threonine, and tyrosine residues. Anti-IgR stimulation induces the increase of the kinase activity coprecipitated with the p160 protein in mature B cell BAL17 and normal adult spleen B cells. This result suggest that the p160-associated kinase activity is one of the downstream events of the IgR-mediated signal transduction cascade. Interestingly, immature B cell lymphoma WEHI-231 and the neonatal spleen B cells showed the adverse reaction of the p160-associated kinase which results in the transient loss of the kinase activity. Moreover, the transient decrease of the p160-associated kinase was caused by the tyrosine phosphatase activity induced by the stimulation of IgR in WEHI-231. The results suggest that this molecular difference in the downstream events of the IgR-mediated signal transduction between immature B cells and mature B cells already begins at the transmembrane level in the IgR-mediated signal transduction pathway. | lld:pubmed |
| pubmed-article:8077655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8077655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8077655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8077655 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8077655 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:IgarashiHH | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:KikuchiKK | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:NomuraJJ | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:InuiSS | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:MatsudaAA | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:SakaguchiNN | lld:pubmed |
| pubmed-article:8077655 | pubmed:author | pubmed-author:KuwaharaKK | lld:pubmed |
| pubmed-article:8077655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8077655 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8077655 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:8077655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8077655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8077655 | pubmed:pagination | 2381-93 | lld:pubmed |
| pubmed-article:8077655 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:meshHeading | pubmed-meshheading:8077655-... | lld:pubmed |
| pubmed-article:8077655 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8077655 | pubmed:articleTitle | B cell Ag receptor mediates different types of signals in the protein kinase activity between immature B cell and mature B cell. | lld:pubmed |
| pubmed-article:8077655 | pubmed:affiliation | Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan. | lld:pubmed |
| pubmed-article:8077655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8077655 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8077655 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8077655 | lld:pubmed |
