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pubmed-article:8076671pubmed:abstractTextThe injection of capsaicin into the lateral gastrocnemius (LG) muscle of the rat induced an immediate and sustained reduction in the A delta and C components of the compound action potential (CAP) of the LG motor nerve. Conversely, the drug did not immediately affect the CAP wave belonging to fast-conducting fibers or the motor responses to LG nerve stimulation. It seems that capsaicin only affects the group III and IV afferents of LG nerve. However, a week after the injection the capsaicin also altered the motor responses, as shown by the threshold enhancement and amplitude reduction of the muscle twitch and by the decrease of the A alpha-beta CAP components. This late motor impairment was attributed to a central depression following a reduction of capsaicin-sensitive neuron input into the CNS. However, this motor effect was transient since the LG nerve regained the preinjection excitability level in a week and the muscle twitch amplitude reached the control value in a month.lld:pubmed
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pubmed-article:8076671pubmed:articleTitleEffects of capsaicin in the motor nerve.lld:pubmed
pubmed-article:8076671pubmed:affiliationInstitute of Human Physiology, University of Perugia, Italy.lld:pubmed
pubmed-article:8076671pubmed:publicationTypeJournal Articlelld:pubmed
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