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pubmed-article:8045567pubmed:abstractTextArrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG alpha and D2S23/D2S55 on chromosome 2q24-37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax = 9.25 at theta = 0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.lld:pubmed
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pubmed-article:8045567pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:8045567pubmed:articleTitleGenetic fine localization of the arrestin (S-antigen) gene 4 cM distal from D2S172.lld:pubmed
pubmed-article:8045567pubmed:affiliationUnitat de Genètica Molecular, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.lld:pubmed
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pubmed-article:8045567pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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