| pubmed-article:8027245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0018120 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0221971 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0018061 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C1571705 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0023607 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C0302891 | lld:lifeskim |
| pubmed-article:8027245 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:8027245 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8027245 | pubmed:dateCreated | 1994-8-5 | lld:pubmed |
| pubmed-article:8027245 | pubmed:abstractText | The amplitude and duration of the midcycle LH surge required for periovulatory changes in the primate follicle are incompletely defined. We reported that short (4- to 14-h) LH surges were insufficient to induce periovulatory events after multiple follicular development in macaques. In contrast, an 18- to 24-h LH surge induced oocyte maturation plus granulosa cell luteinization, but did not support corpus luteum function. In this study, the periovulatory changes following LH surges of 48 h elicited using pituitary (pit) or recombinant (r) human (h) LH were compared to those after 24-h LH surge durations or after urinary hCG (u-hCG) treatment. Beginning at menses, rhesus monkeys were treated with human gonadotropins for 9 days to stimulate follicular growth. On day 10, animals (n = 3-5/group) received 1) a single injection of u-hCG [79 +/- 3 micrograms RP-1 equivalents (equiv), im], 2) two injections of pit-hLH (91 +/- 4 micrograms RP-1 equiv, im), 3) one injection of r-hLH (21 +/- 1 micrograms RP-1 equiv, im), or 4) two injections of r-hLH (21 +/- 1 micrograms RP-1 equiv). Oocytes and granulosa cells were obtained via follicle aspiration 27 h after the initial LH or hCG injection. In all groups, serum estradiol rose to similar peak levels by day 10. Circulating LH-like bioactivity was elevated for more than 48 h after u-hCG. Peak serum LH bioactivities were proportional to the administered LH doses, as determined in the in vitro bioassay. Two injections of either r-hLH or pit-hLH elicited surge levels (> 100 ng/mL) of bioactive LH for 36-48 h, whereas one injection sustained surge levels for only 18-24 h. The proportions of oocytes resuming meiosis (68-76%) were similar in all groups. Immunocytochemical staining for progesterone receptor and in vitro progesterone production by granulosa cells in all LH-treated groups were comparable to those of cells form the hCG-treated group. Peak levels of progesterone in the luteal phase were comparable in monkeys treated with two doses of pit-hLH and r-hLH (18.5 +/- 10.4 vs. 8.1 +/- 1.5 ng/mL) and approached that in u-hCG treated monkeys (39.5 +/- 18.0 ng/mL). However, progesterone levels in animals treated once with r-hLH (3.4 +/- 1.5 ng/mL) were less (P < 0.05) than those in u-hCG-treated monkeys.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
| pubmed-article:8027245 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8027245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8027245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8027245 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8027245 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:WolfD PDP | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:HutchisonJ... | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:HessD LDL | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:StoufferR LRL | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:Chandrasekher... | lld:pubmed |
| pubmed-article:8027245 | pubmed:author | pubmed-author:Zelinski-Woot... | lld:pubmed |
| pubmed-article:8027245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8027245 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:8027245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8027245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8027245 | pubmed:pagination | 298-306 | lld:pubmed |
| pubmed-article:8027245 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
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| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:meshHeading | pubmed-meshheading:8027245-... | lld:pubmed |
| pubmed-article:8027245 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8027245 | pubmed:articleTitle | Initiation of periovulatory events in primate follicles using recombinant and native human luteinizing hormone to mimic the midcycle gonadotropin surge. | lld:pubmed |
| pubmed-article:8027245 | pubmed:affiliation | Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006. | lld:pubmed |
| pubmed-article:8027245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8027245 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8027245 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8027245 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8027245 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8027245 | lld:pubmed |
