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pubmed-article:8025810pubmed:abstractTextSuppression of the water signal during 1H magnetic resonance spectroscopy by repeated sequences of a frequency-selective radiofrequency pulse and a gradient dephasing pulse requires nulling of the longitudinal component of the water magnetization and is therefore affected by T1 relaxation, RF-pulse flip angles (which depend on B1), and sequence timing. In in vivo applications, T1 and B1 inhomogeneity within the sample may cause spatially inhomogeneous water suppression. An improved water-suppression technique called WET (water suppression enhanced through T1 effects), developed from a Bloch equation analysis of the longitudinal magnetization over the T1 and B1 ranges of interest, achieves T1- and B1-insensitive suppression with four RF pulses, each having a numerically optimized flip angle. Once flip angles have been optimized for a given sequence, time-consuming flip-angle adjustments during clinical examinations are eliminated. This water-suppression technique was characterized with respect to T1 variations, B1 variations, off-resonance effects, and partial saturation effects and was compared to similar techniques. Effective water suppression has been achieved with this new technique in single-voxel spectroscopy examinations of more than 50 brain tumor patients at 1.5 T.lld:pubmed
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pubmed-article:8025810pubmed:authorpubmed-author:KingsleyP BPBlld:pubmed
pubmed-article:8025810pubmed:authorpubmed-author:TaylorJ SJSlld:pubmed
pubmed-article:8025810pubmed:authorpubmed-author:FoxI SISlld:pubmed
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pubmed-article:8025810pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8025810pubmed:year1994lld:pubmed
pubmed-article:8025810pubmed:articleTitleWET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy.lld:pubmed
pubmed-article:8025810pubmed:affiliationDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.lld:pubmed
pubmed-article:8025810pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8025810pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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