| pubmed-article:8008069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8008069 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:8008069 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8008069 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:8008069 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8008069 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8008069 | pubmed:issue | 6483 | lld:pubmed |
| pubmed-article:8008069 | pubmed:dateCreated | 1994-7-19 | lld:pubmed |
| pubmed-article:8008069 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:abstractText | The structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting complexes interfere with distinct signalling pathways. FKBP12-rapamycin inhibits progression through the G1 phase of the cell cycle in osteosarcoma, liver and T cells as well as in yeast, and interferes with mitogenic signalling pathways that are involved in G1 progression, namely with activation of the protein p70S6k (refs 5, 11-13) and cyclin-dependent kinases. Here we isolate a mammalian FKBP-rapamycin-associated protein (FRAP) whose binding to structural variants of rapamycin complexed to FKBP12 correlates with the ability of these ligands to inhibit cell-cycle progression. Peptide sequences from purified bovine FRAP were used to isolate a human cDNA clone that is highly related to the DRR1/TOR1 and DRR2/TOR2 gene products from Saccharomyces cerevisiae. Although it has not been previously demonstrated that either of the DRR/TOR gene products can bind the FKBP-rapamycin complex directly, these yeast genes have been genetically linked to a rapamycin-sensitive pathway and are thought to encode lipid kinases. | lld:pubmed |
| pubmed-article:8008069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8008069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8008069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8008069 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8008069 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:IchikawaKK | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:BrownE JEJ | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:MatzR JRJ | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:KeithC TCT | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:SchreiberS... | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:ShinT BTB | lld:pubmed |
| pubmed-article:8008069 | pubmed:author | pubmed-author:AlbersM WMW | lld:pubmed |
| pubmed-article:8008069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8008069 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:8008069 | pubmed:volume | 369 | lld:pubmed |
| pubmed-article:8008069 | pubmed:geneSymbol | TOR1 | lld:pubmed |
| pubmed-article:8008069 | pubmed:geneSymbol | TOR2 | lld:pubmed |
| pubmed-article:8008069 | pubmed:geneSymbol | DRR1 | lld:pubmed |
| pubmed-article:8008069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8008069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8008069 | pubmed:pagination | 756-8 | lld:pubmed |
| pubmed-article:8008069 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:meshHeading | pubmed-meshheading:8008069-... | lld:pubmed |
| pubmed-article:8008069 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8008069 | pubmed:articleTitle | A mammalian protein targeted by G1-arresting rapamycin-receptor complex. | lld:pubmed |
| pubmed-article:8008069 | pubmed:affiliation | Department of Chemistry, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138. | lld:pubmed |
| pubmed-article:8008069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8008069 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8008069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://bio2rdf.org/pubmed:8... | skos:relatedMatch | pubmed-article:8008069 | lld:mappings |
| entrez-gene:2475 | entrezgene:pubmed | pubmed-article:8008069 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8008069 | lld:pubmed |
