| pubmed-article:8006601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0441833 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0010837 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0030940 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1999270 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1301820 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8006601 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8006601 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8006601 | pubmed:dateCreated | 1994-7-21 | lld:pubmed |
| pubmed-article:8006601 | pubmed:abstractText | The ear, skin, and purified serosal mast cells of WBB6F1/J-(+/+) (WB-(+/+)) and WCB6F1/J-(+/+) (WC-(+/+)) mice contain high steady-state levels of the transcripts that encode mouse mast cell protease (mMCP) 2, mMCP-4, mMCP-5, mMCP-6, and mouse mast cell carboxypeptidase A (mMC-CPA). In contrast, no mast cell protease transcripts are present in abundance in the ear and skin of WBB6F1/J-W/Wv (W/Wv) and WCB6F1/J-Sl/Sld (Sl/Sld) mice which are mast cell-deficient in vivo due to defects in their c-kit and c-kit ligand genes, respectively. We now report that the immature bone marrow-derived mast cells (mBMMC) obtained in vitro with recombinant interleukin 3 (rIL-3) or WEHI-3 cell conditioned medium from WB-(+/+), WC-(+/+), W/Wv, and Sl/Sld mice all contain high steady-state levels of the mMCP-2, mMCP-4, mMCP-5, mMCP-6, and mMC-CPA transcripts. As assessed immunohistochemically, mMCP-2 protein and mMCP-5 protein are also present in the granules of mBMMC from WB-(+/+), WC-(+/+), and W/Wv mice. That Sl/Sld and W/Wv mBMMC contain high steady-state levels of five granule protease transcripts expressed by the mature serosal, ear, and skin mast cells of their normal +/+ littermates suggests that c-kit-mediated signal transduction is not essential for inducing transcription of these protease genes. Because rIL-4 inhibits the rIL-10-induced expression of mMCP-1 and mMCP-2 in BALB/cJ mBMMC, the ability of rIL-4 to influence protease mRNA levels in WC-(+/+) mBMMC and W/Wv mBMMC was investigated. Although rIL-10 induced expression of the mMCP-1 transcript in WC-(+/+) and W/Wv mBMMC, rIL-4 was not able to suppress the steady-state levels of the mMCP-1 transcript or any other protease transcript in these cultured mast cells. Thus, not only do BALB/cJ mBMMC express fewer granule proteases than mBMMC from mast cell-deficient strains and their normal littermates but the subsequent induction of late-expressed proteases in BALB/cJ mBMMC is more tightly regulated by IL-3 and IL-4. | lld:pubmed |
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| pubmed-article:8006601 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8006601 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8006601 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8006601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8006601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8006601 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8006601 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:AustenK FKF | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:StevensR LRL | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:FriendD SDS | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:SchillerVV | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:GhildyalNN | lld:pubmed |
| pubmed-article:8006601 | pubmed:author | pubmed-author:EklundK KKK | lld:pubmed |
| pubmed-article:8006601 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8006601 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8006601 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:8006601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8006601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8006601 | pubmed:pagination | 67-73 | lld:pubmed |
| pubmed-article:8006601 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:meshHeading | pubmed-meshheading:8006601-... | lld:pubmed |
| pubmed-article:8006601 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8006601 | pubmed:articleTitle | Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. | lld:pubmed |
| pubmed-article:8006601 | pubmed:affiliation | Department of Medicine, Harvard Medical School, Boston, Massachusetts. | lld:pubmed |
