| pubmed-article:7998967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0007301 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0205242 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0081487 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0172956 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:7998967 | lifeskim:mentions | umls-concept:C0247689 | lld:lifeskim |
| pubmed-article:7998967 | pubmed:dateCreated | 1995-1-13 | lld:pubmed |
| pubmed-article:7998967 | pubmed:abstractText | Native and recombinant neutrophil collagenase (MMP-8) was shown to cleave at the E373-A374 'aggrecanase' site in the interglobular domain of aggrecan. The time course of digestion in vitro showed that MMP-8 cleaved initially at N341-F342, the predominant metalloproteinase site, before cleaving at the E373-A374 site. A synthetic peptide, IPENFFG, inhibited cleavage at E373-A374 but not N341-F342 in vitro, indicating that the E373-A374 sequence was a less preferred site for MMP-8 cleavage than N341-F342. IPENFFG also inhibited release of A374 RGSVI fragments from cartilage in explant culture, suggesting that a metalloproteinase cleaved at the aggrecanase site in situ. The possibility remains that 'aggrecanase' may be a metalloproteinase in cartilage. | lld:pubmed |
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| pubmed-article:7998967 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7998967 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7998967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7998967 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7998967 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:TschescheHH | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:HardinghamT... | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:MurphyGG | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:CatersonBB | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:HughesC ECE | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:NeameP JPJ | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:KnäuperVV | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:GüssHH | lld:pubmed |
| pubmed-article:7998967 | pubmed:author | pubmed-author:FosangA JAJ | lld:pubmed |
| pubmed-article:7998967 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7998967 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7998967 | pubmed:volume | 304 ( Pt 2) | lld:pubmed |
| pubmed-article:7998967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7998967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7998967 | pubmed:pagination | 347-51 | lld:pubmed |
| pubmed-article:7998967 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7998967 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7998967 | pubmed:articleTitle | Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. | lld:pubmed |
| pubmed-article:7998967 | pubmed:affiliation | University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia. | lld:pubmed |
| pubmed-article:7998967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7998967 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7998967 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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