| pubmed-article:7972691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7972691 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:7972691 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:7972691 | lifeskim:mentions | umls-concept:C0018296 | lld:lifeskim |
| pubmed-article:7972691 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:7972691 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7972691 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7972691 | pubmed:dateCreated | 1994-12-27 | lld:pubmed |
| pubmed-article:7972691 | pubmed:abstractText | Initial findings from our laboratory have indicated that muscarinic enhancement of K(+)-evoked release of dopamine from perifused striatal slices is reduced after exposure to 56Fe-particle irradiation. This finding suggested that there is a radiation-induced deficit in muscarinic receptor sensitivity. Subsequent findings have indicated that at least part of the loss in sensitivity may occur as a result of alterations in the initial steps of the signal transduction process and involve muscarinic receptor-G protein coupling/uncoupling. The present study was carried out to localize this deficit further by determining carbachol-stimulated low-Km guanosine triphosphatase (GTPase) activity in striatal and hippocampal tissue obtained from rats exposed to 0, 0.1 or 1.0 Gy of 56Fe-particle irradiation. In addition, to examine the specificity of the effect of 56Fe-particle irradiation, alpha 1-adrenergic-stimulated low-Km GTPase activity was also examined in these tissues. The results showed that there was a high degree of specificity in the effects of 56Fe particles. Decrements were observed in muscarinic-stimulated low-Km GTPase in striatum but not in hippocampus, and 56Fe-particle irradiation did not affect alpha 1-adrenergic low-Km GTPase activity in either brain tissue. | lld:pubmed |
| pubmed-article:7972691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7972691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7972691 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7972691 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:JosephJ AJA | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:DaltonT KTK | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:RothG SGS | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:KandasamyS... | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:RabinB MBM | lld:pubmed |
| pubmed-article:7972691 | pubmed:author | pubmed-author:Villalobos-Mo... | lld:pubmed |
| pubmed-article:7972691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7972691 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:7972691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7972691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7972691 | pubmed:pagination | 382-6 | lld:pubmed |
| pubmed-article:7972691 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
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| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
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| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:meshHeading | pubmed-meshheading:7972691-... | lld:pubmed |
| pubmed-article:7972691 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7972691 | pubmed:articleTitle | Iron-56 irradiation diminishes muscarinic but not alpha 1-adrenergic-stimulated low-Km GTPase in rat brain. | lld:pubmed |
| pubmed-article:7972691 | pubmed:affiliation | Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224. | lld:pubmed |
| pubmed-article:7972691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7972691 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7972691 | lld:pubmed |
