| pubmed-article:7947466 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7947466 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7947466 | lifeskim:mentions | umls-concept:C0206123 | lld:lifeskim |
| pubmed-article:7947466 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7947466 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7947466 | pubmed:dateCreated | 1994-12-6 | lld:pubmed |
| pubmed-article:7947466 | pubmed:abstractText | We observed that peripheral T cells activated in vivo or in vitro by superantigens are susceptible to cell death when their antigen receptor is cross-linked with the appropriate anti-alpha beta TCR mAb. TCR ligation by mAbs specifically drove the T cell clonal deletion in both CD4+ and CD8+ cell subsets. An IL-2/IL-2R interaction seems to be a critical step in predisposing superantigen activated cells to death; in fact, in vivo IL-2R blockade reversed T cell deletion in superantigen plus anti-alpha beta TCR mAb treated mice. TCR ligation by mAbs also produced cell death of the relevant targets in in vitro IL-2 activated T cells. Surprisingly, no T cell deletion was demonstrable in IL-2 activated cells following staphylococcal enterotoxin B--TCR interaction, ruling out the possibility that superantigen in itself can induce cell death. Thus, while superantigen activation opens the cell death program, a subsequent TCR--antigen (self) interaction appears necessary to produce clonal deletion in mature T lymphocytes. | lld:pubmed |
| pubmed-article:7947466 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7947466 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7947466 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7947466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7947466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7947466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7947466 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7947466 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7947466 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:7947466 | pubmed:author | pubmed-author:BiasiGG | lld:pubmed |
| pubmed-article:7947466 | pubmed:author | pubmed-author:PanozzoMM | lld:pubmed |
| pubmed-article:7947466 | pubmed:author | pubmed-author:FacchinettiAA | lld:pubmed |
| pubmed-article:7947466 | pubmed:author | pubmed-author:PertilePP | lld:pubmed |
| pubmed-article:7947466 | pubmed:author | pubmed-author:MezzaliraSS | lld:pubmed |
| pubmed-article:7947466 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7947466 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:7947466 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7947466 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7947466 | pubmed:pagination | 983-9 | lld:pubmed |
| pubmed-article:7947466 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7947466 | pubmed:meshHeading | pubmed-meshheading:7947466-... | lld:pubmed |
| pubmed-article:7947466 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7947466 | pubmed:articleTitle | Mechanism underlying superantigen-induced clonal deletion of mature T lymphocytes. | lld:pubmed |
| pubmed-article:7947466 | pubmed:affiliation | Institute of Experimental Pathology, Ancona, Italy. | lld:pubmed |
| pubmed-article:7947466 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7947466 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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