| pubmed-article:7935853 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0042360 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7935853 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7935853 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7935853 | pubmed:dateCreated | 1994-11-16 | lld:pubmed |
| pubmed-article:7935853 | pubmed:abstractText | The effect of P1-purinoceptor activation on contractions, release of noradrenaline and release of ATP elicited by electrical field stimulation (210 pulses, 7 Hz) was studied in the superfused vas deferens of the guinea pig. Release of noradrenaline was assessed as overflow of total tritium after preincubation with [3H]-noradrenaline. ATP was measured by means of the luciferin-luciferase technique. Electrical stimulation elicited reproducible contraction, tritium overflow and ATP overflow. In the absence of other drugs, adenosine (10-100 microM) did not change evoked contractions but reduced the evoked overflow of tritium and ATP. In subsequent experiments alpha 1-adrenoceptors were blocked by prazosin, P2-purinoceptors by suramin and alpha 2-adrenoceptors by rauwolscine. No or almost no contraction remained under these conditions. The evoked overflow of tritium was 505% and the evoked overflow of ATP 34% of that observed in the absence of prazosin, suramin and rauwolscine. Adenosine (1-100 microM) again reduced the evoked overflow of tritium and ATP, and so did the A1-selective agonist 2-chloro-N6-cyclopentyladenosine (CCPA; 0.032-0.32 microM). Adenosine and CCPA decreased the evoked overflow of ATP to a greater extent than the evoked overflow of tritium. It is concluded that neural release of both postganglionic sympathetic cotransmitters, noradrenaline and ATP, is decreased upon activation of prejunctional P1- (A1-) purinoceptors in guinea-pig vas deferens. The A1-receptor-mediated inhibition of the release of ATP is more marked than the inhibition of the release of noradrenaline, a pattern opposite to the inhibition produced by activation of prejunctional alpha 2-autoreceptors. | lld:pubmed |
| pubmed-article:7935853 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7935853 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7935853 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7935853 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7935853 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7935853 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7935853 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:7935853 | pubmed:author | pubmed-author:StarkeKK | lld:pubmed |
| pubmed-article:7935853 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:7935853 | pubmed:author | pubmed-author:DriessenBB | lld:pubmed |
| pubmed-article:7935853 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7935853 | pubmed:volume | 350 | lld:pubmed |
| pubmed-article:7935853 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7935853 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7935853 | pubmed:pagination | 42-8 | lld:pubmed |
| pubmed-article:7935853 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7935853 | pubmed:meshHeading | pubmed-meshheading:7935853-... | lld:pubmed |
| pubmed-article:7935853 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7935853 | pubmed:articleTitle | P1-purinoceptor-mediated modulation of neural noradrenaline and ATP release in guinea-pig vas deferens. | lld:pubmed |
| pubmed-article:7935853 | pubmed:affiliation | Pharmakologisches Institut, Universität Freiburg, Germany. | lld:pubmed |
| pubmed-article:7935853 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7935853 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7935853 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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