| pubmed-article:7935375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C1148798 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0600508 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C1517317 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C0872243 | lld:lifeskim |
| pubmed-article:7935375 | lifeskim:mentions | umls-concept:C1511573 | lld:lifeskim |
| pubmed-article:7935375 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7935375 | pubmed:dateCreated | 1994-10-21 | lld:pubmed |
| pubmed-article:7935375 | pubmed:abstractText | We recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factors and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5' of the TIS10/PGS2 transcription start site that mediates pp60v-src induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E-box (CACGTG) sequences. Gel shift-oligonucleotide competition experiments with nuclear extracts from cells stably transfected with a temperature-sensitive v-src gene demonstrate that the CGTCACGTG sequence can bind proteins at both the ATF/CRE and E-box sequences. Dominant-negative CREB and Myc proteins that bind DNA, but do not transactivate, block v-src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10/PGS2 promoter. Mutational analysis distinguishes which TIS10/PGS2 cis-acting element mediates pp60v-src induction. E-box mutation has no effect on the fold induction in response to pp60v-src. In contrast, ATF/CRE mutation attenuates the pp60v-src response. Antibody supershift and methylation interference experiments demonstrate that CREB and at least one other ATF transcription factor in these extracts bind to the TIS10/PGS2 ATF/CRE element. Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src. Our data suggest that Ras mediates pp60v-src activation of an ATF transcription factor, leading to induced TIS10/PGS2 expression via the ATF/CRE element of the TIS10/PGS2 promoter. This is the first description of v-src activation of gene expression via an ATF/CRE element. | lld:pubmed |
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| pubmed-article:7935375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7935375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7935375 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7935375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7935375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7935375 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7935375 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7935375 | pubmed:author | pubmed-author:HerschmanH... | lld:pubmed |
| pubmed-article:7935375 | pubmed:author | pubmed-author:AndersenR DRD | lld:pubmed |
| pubmed-article:7935375 | pubmed:author | pubmed-author:XiaSS | lld:pubmed |
| pubmed-article:7935375 | pubmed:author | pubmed-author:FletcherB SBS | lld:pubmed |
| pubmed-article:7935375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7935375 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7935375 | pubmed:owner | NLM | lld:pubmed |
