| pubmed-article:7914078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C0074830 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C1335867 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:7914078 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:7914078 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7914078 | pubmed:dateCreated | 1994-9-1 | lld:pubmed |
| pubmed-article:7914078 | pubmed:abstractText | Somatostatin has been shown to exert diverse biological effects in various tissues. Recently, the human genes encoding five subtypes of somatostatin receptor (SSTR1-SSTR5) were cloned. Among these subtypes SSTR2 is present in many endocrine tumors as well as normal tissues and may mediate the effects of somatostatin analog, SMS201-995. In this study, we have investigated the intracellular effect of SSTR2 stably expressed in Chinese hamster ovary cells. Somatostatin-14 does not affect the forskolin stimulated cAMP formation when human SSTR2 is expressed in CHO cells, which lack internal Gi alpha 1 protein. However, somatostatin-14 inhibits the adenylyl cyclase in a dose dependent and pertussis toxin-sensitive manner when human SSTR2 is co-expressed with Gi alpha 1 in CHO cells. These results indicate that human SSTR2 is functionally coupled to Gi alpha 1 protein but not to Gi alpha 2 or Gi alpha 3 when expressed in CHO cells. | lld:pubmed |
| pubmed-article:7914078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7914078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7914078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7914078 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7914078 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:YamadaYY | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:ImuraHH | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:KubotaAA | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:SeinoYY | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:YasudaKK | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:IharaYY | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:SeinoSS | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:SomeyaYY | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:KagimotoSS | lld:pubmed |
| pubmed-article:7914078 | pubmed:author | pubmed-author:KozasaTT | lld:pubmed |
| pubmed-article:7914078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7914078 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:7914078 | pubmed:volume | 202 | lld:pubmed |
| pubmed-article:7914078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7914078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7914078 | pubmed:pagination | 1188-95 | lld:pubmed |
| pubmed-article:7914078 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7914078 | pubmed:meshHeading | pubmed-meshheading:7914078-... | lld:pubmed |
| pubmed-article:7914078 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7914078 | pubmed:articleTitle | Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. | lld:pubmed |
| pubmed-article:7914078 | pubmed:affiliation | Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan. | lld:pubmed |
| pubmed-article:7914078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7914078 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2770 | entrezgene:pubmed | pubmed-article:7914078 | lld:entrezgene |
| entrez-gene:6752 | entrezgene:pubmed | pubmed-article:7914078 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:7914078 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7914078 | lld:pubmed |
