| pubmed-article:7912491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0030551 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0376622 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0038880 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0439661 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7912491 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7912491 | pubmed:issue | 2A | lld:pubmed |
| pubmed-article:7912491 | pubmed:dateCreated | 1994-7-25 | lld:pubmed |
| pubmed-article:7912491 | pubmed:abstractText | Suramin at 100 to 800 micrograms/ml caused a dose dependent growth inhibition in three (Zr-75-1, BT 549 and HS-578T) parental human breast cancer cell lines and their corresponding sublines with acquired doxorubicin (dox) and multi-drug resistance. The effect was significantly more marked after 7 days suramin exposure compared with 3 days. The oestrogen and progesterone receptor rich cell line Zr-75-1 was more responsive to suramin compared with the other two lines. The sublines Zr-75-1-dox and HS-578T-dox with an increased expression of the permeability glycoprotein (P-gp) demonstrated a significantly decreased cell survival compared with corresponding parental cell lines at 3 and 7 days exposure of suramin, respectively. The subline BT 549-dox with multi-drug resistance without P-gp expression had a significantly impaired response after 3 days suramin compared with the parental line. These results indicate that suramin may be a potential therapeutic agent for the breast cancer patients with P-gp expression and multi-drug resistance. | lld:pubmed |
| pubmed-article:7912491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7912491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7912491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7912491 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:7912491 | pubmed:author | pubmed-author:TaubeAA | lld:pubmed |
| pubmed-article:7912491 | pubmed:author | pubmed-author:LindmanHH | lld:pubmed |
| pubmed-article:7912491 | pubmed:author | pubmed-author:BerghJ CJC | lld:pubmed |
| pubmed-article:7912491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7912491 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7912491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7912491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7912491 | pubmed:pagination | 363-6 | lld:pubmed |
| pubmed-article:7912491 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7912491 | pubmed:meshHeading | pubmed-meshheading:7912491-... | lld:pubmed |
| pubmed-article:7912491 | pubmed:meshHeading | pubmed-meshheading:7912491-... | lld:pubmed |
| pubmed-article:7912491 | pubmed:meshHeading | pubmed-meshheading:7912491-... | lld:pubmed |
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| pubmed-article:7912491 | pubmed:meshHeading | pubmed-meshheading:7912491-... | lld:pubmed |
| pubmed-article:7912491 | pubmed:articleTitle | Suramin inhibits the growth of human breast cancer cell lines. Studies on parental lines and corresponding sublines with acquired doxorubicin resistance with and without expression of P-glycoprotein. | lld:pubmed |
| pubmed-article:7912491 | pubmed:affiliation | Department of Oncology, Akademiska Sjukhuset, University of Uppsala, Sweden. | lld:pubmed |
| pubmed-article:7912491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7912491 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7912491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7912491 | lld:pubmed |
