| pubmed-article:791102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:791102 | lifeskim:mentions | umls-concept:C0025872 | lld:lifeskim |
| pubmed-article:791102 | lifeskim:mentions | umls-concept:C0028179 | lld:lifeskim |
| pubmed-article:791102 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:791102 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:791102 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:791102 | pubmed:dateCreated | 1976-12-23 | lld:pubmed |
| pubmed-article:791102 | pubmed:abstractText | Twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on Tritrichomonas foetus (KV(1)) and Trichomonas vaginalis (ATCC 30001) for mutagenicity on a nitroreductase-positive (TA 100) and a nitroreductase-deficient (TA 100-FR(1)) strain of Salmonella typhimurium, as well as for the reducibility of the nitro group by T. foetus homogenates. Compounds with activity <1% of that of metronidazole are regarded as inactive. All antitrichomonad compounds induce mutations and can be reduced. S. typhimurium TA 100 gave mutations under both aerobiosis and anaerobiosis; TA 100-FR(1), however, gave mutations only under anaerobiosis. Certain compounds that are reducible, and the nonreducible derivatives, were inactive. Metronidazole and its inactive 4-nitro analogue were reduced in a four-electron process in ferredoxin- or methyl viologen-mediated reactions with the same velocity. The results underscore the role of the reduction of the nitro group in the antitrichomonad and in the mutagenic activity of nitroimidazoles. | lld:pubmed |
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| pubmed-article:791102 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:791102 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:791102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:791102 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:791102 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:791102 | pubmed:author | pubmed-author:MüllerMM | lld:pubmed |
| pubmed-article:791102 | pubmed:author | pubmed-author:LindmarkD GDG | lld:pubmed |
| pubmed-article:791102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:791102 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:791102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:791102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:791102 | pubmed:pagination | 476-82 | lld:pubmed |
| pubmed-article:791102 | pubmed:dateRevised | 2010-9-3 | lld:pubmed |
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| pubmed-article:791102 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:791102 | pubmed:articleTitle | Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles. | lld:pubmed |
| pubmed-article:791102 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:791102 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:791102 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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