| pubmed-article:7909141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0013336 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:7909141 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:7909141 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7909141 | pubmed:dateCreated | 1994-5-19 | lld:pubmed |
| pubmed-article:7909141 | pubmed:abstractText | Mice homozygous for the recessive 'Ames' dwarf mutation have undetectable serum or pituitary prolactin (PRL). Accompanying this pituitary deficiency is a marked reduction of dopamine (DA) and its rate-limiting synthetic enzyme tyrosine hydroxylase (TH) in PRL-regulating tuberoinfundibular hypothalamic neurons. In order to determine whether this deficit in adult Ames dwarf mice is congenital or arises postnatally, brains of dwarf (df/df) and normal (DF/?) littermate mice were assessed for TH immunoreactivity from 7 days through 2 months of age. Numbers of TH-positive neurons were counted in three hypothalamic DA areas: tuberoinfundibular A12, medial zona incerta A13, and anterior periventricular A14. There was an increase in the number of TH-positive neurons between 7 and 21 days of age in A12 and A14, but not in A13, for both DF/? and df/df mice. Between 21 days and 2 months of age, cell numbers were the same in all three areas in DF/? mice and in A13 and A14 in df/df mice. However, A12 TH-positive cell number in dwarfs decreased significantly (p < 0.01) between 21 days and 2 months, and was markedly lower (p < 0.001) in df/df than in DF/? mice at 2 months of age. The results emphasize the specificity of the dopaminergic neuron reduction in the Ames dwarf, which is restricted to the PRL-regulating tuberoinfundibular region. The data also indicate that the dwarf DA/TH deficit has an onset in late postnatal development, suggesting a response to absence of target PRL, rather than a primary hypothalamic effect of the dwarf mutation. | lld:pubmed |
| pubmed-article:7909141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7909141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7909141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7909141 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7909141 | pubmed:issn | 0028-3835 | lld:pubmed |
| pubmed-article:7909141 | pubmed:author | pubmed-author:HurleyD LDL | lld:pubmed |
| pubmed-article:7909141 | pubmed:author | pubmed-author:RomeroM IMI | lld:pubmed |
| pubmed-article:7909141 | pubmed:author | pubmed-author:PhelpsC JCJ | lld:pubmed |
| pubmed-article:7909141 | pubmed:author | pubmed-author:VaccarellaM... | lld:pubmed |
| pubmed-article:7909141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7909141 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:7909141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7909141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7909141 | pubmed:pagination | 189-96 | lld:pubmed |
| pubmed-article:7909141 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:meshHeading | pubmed-meshheading:7909141-... | lld:pubmed |
| pubmed-article:7909141 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7909141 | pubmed:articleTitle | Postnatal reduction in number of hypothalamic tuberoinfundibular dopaminergic neurons in prolactin-deficient dwarf mice. | lld:pubmed |
| pubmed-article:7909141 | pubmed:affiliation | Department of Anatomy, Tulane University School of Medicine, New Orleans, LA 70112. | lld:pubmed |
| pubmed-article:7909141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7909141 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:19127 | entrezgene:pubmed | pubmed-article:7909141 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7909141 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7909141 | lld:pubmed |
