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| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7895156 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:7895156 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7895156 | pubmed:dateCreated | 1995-4-25 | lld:pubmed |
| pubmed-article:7895156 | pubmed:abstractText | Using a neutralizing monoclonal antibody specific for murine IFN gamma we show that endogenously produced IFN gamma plays an obligate role in mediating LPS-induced rejection of the Meth A fibrosarcoma tumor in syngeneic BALB/c mice. To examine the cellular targets of IFN gamma action, we generated IFN gamma-insensitive tumor cells by stably overexpressing in Meth A a truncated dominant negative form of the murine IFN gamma receptor alpha chain. When implanted in BALB/c mice, IFN gamma-insensitive Meth A cells displayed enhanced tumorigenicity compared with control Meth A cells and were not rejected when tumor-bearing mice were treated with concentrations of LPS that eliminated control tumors. In Meth A immune mice, IFN gamma-insensitive Meth A did not establish tumors while IFN gamma-insensitive tumors grew in a progressive manner. In addition, the IFN gamma-insensitive tumor cells were unable to elicit strong protective immunity to subsequent wild-type tumor challenge. These results show that IFN gamma has direct effects on tumor cell immunogenicity and thus plays an important role in promoting tumor cell recognition and elimination. | lld:pubmed |
| pubmed-article:7895156 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7895156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7895156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7895156 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7895156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7895156 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7895156 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:7895156 | pubmed:author | pubmed-author:RichardsEE | lld:pubmed |
| pubmed-article:7895156 | pubmed:author | pubmed-author:OldL JLJ | lld:pubmed |
| pubmed-article:7895156 | pubmed:author | pubmed-author:SchreiberR... | lld:pubmed |
| pubmed-article:7895156 | pubmed:author | pubmed-author:DigheA SAS | lld:pubmed |
| pubmed-article:7895156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7895156 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:7895156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7895156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7895156 | pubmed:pagination | 447-56 | lld:pubmed |
| pubmed-article:7895156 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7895156 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7895156 | pubmed:articleTitle | Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors. | lld:pubmed |
| pubmed-article:7895156 | pubmed:affiliation | Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110. | lld:pubmed |
| pubmed-article:7895156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7895156 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7895156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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