| pubmed-article:7882570 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7882570 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:7882570 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7882570 | lifeskim:mentions | umls-concept:C0073992 | lld:lifeskim |
| pubmed-article:7882570 | lifeskim:mentions | umls-concept:C2244989 | lld:lifeskim |
| pubmed-article:7882570 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:7882570 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7882570 | pubmed:dateCreated | 1995-4-10 | lld:pubmed |
| pubmed-article:7882570 | pubmed:abstractText | Elevation of intracellular cAMP levels has been shown previously to inhibit cytokine secretion by various cell types in vitro. Since salmeterol is a beta 2-agonist which activates adenylate cyclase, its ability to inhibit cytokine production was evaluated. Though salmeterol, and the related drug albuterol, did not inhibit IL-1 beta production in vitro, both drugs did inhibit tumour necrosis factor-alpha (TNF-alpha) secretion by lipopolysaccharide (LPS)-activated THP-1 cells with similar IC50s of approximately 0.1 microM. This inhibition was effectively reversed by the beta 2-antagonist oxprenolol, indicating that the inhibition was mediated through the beta 2-adrenergic receptor. A strikingly different reactivity profile was seen with T cells. Salmeterol was able to inhibit the activation of both mouse and human T cells, as measured by proliferation and IL-2 secretion in response to anti-CD3 antibody, whereas albuterol was completely inactive in these assays. This T cell inhibition by salmeterol was about 10-fold less potent than that for TNF-alpha production, and was not reversed by a beta 2-antagonist, indicating that a different mechanism was involved in the effect of salmeterol on T cells. Paralleling the TNF-alpha inhibitory activity in vitro, oral dosing of salmeterol and albuterol inhibited LPS-induced increase in murine serum TNF level in vivo, with ED50s of approximately 0.1 mg/kg. This inhibition could be abrogated by dosing orally with the beta-blocker propranolol. The long-acting pharmacological profile of salmeterol was apparent in that it maintained its efficacy for 3 h, while albuterol had a much shorter duration of action. Salmeterol also had some protective effects in the galactosamine/LPS model of endotoxic shock, which is dependent upon TNF-alpha production. Though salmeterol inhibited serum TNF-alpha levels by up to 94% in this assay, it protected less than 50% of the animals from the lethal effects of the LPS/galactosamine mixture. This observation suggests that functional levels of TNF-alpha localized in tissues may not be accurately reflected by serum levels. | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7882570 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882570 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7882570 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7882570 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:7882570 | pubmed:author | pubmed-author:ConnollyK MKM | lld:pubmed |
| pubmed-article:7882570 | pubmed:author | pubmed-author:ChampionB RBR | lld:pubmed |
| pubmed-article:7882570 | pubmed:author | pubmed-author:MeniusJ AJAJr | lld:pubmed |
| pubmed-article:7882570 | pubmed:author | pubmed-author:PageKK | lld:pubmed |
| pubmed-article:7882570 | pubmed:author | pubmed-author:SekutLL | lld:pubmed |
| pubmed-article:7882570 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7882570 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:7882570 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7882570 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7882570 | pubmed:pagination | 461-6 | lld:pubmed |
| pubmed-article:7882570 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:meshHeading | pubmed-meshheading:7882570-... | lld:pubmed |
| pubmed-article:7882570 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7882570 | pubmed:articleTitle | Anti-inflammatory activity of salmeterol: down-regulation of cytokine production. | lld:pubmed |
| pubmed-article:7882570 | pubmed:affiliation | Department of Cell Physiology, Glaxo Research Institute, Glaxo Inc., Research Triangle Park, NC 27709. | lld:pubmed |
| pubmed-article:7882570 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7882570 | lld:pubmed |
