| pubmed-article:7872525 | pubmed:abstractText | Concerning the pharmacokinetic or pharmacodynamic interactions, the following is recommended: Use smaller doses of alfentanil when the latter is combined with propofol, because of a higher risk of ventilatory depression. Decrease doses of each agent whenever propofol is combined with thiopentone or midazolam to induce anaesthesia. The prophylactic or therapeutic use of atropine is indicated when propofol is associated with agents reducing heart rate. Prefer propofol to induce anaesthesia for eye surgery, if suxamethonium is required. In the absence of sufficient data, propofol should be administered with care in patients taking cardiovascular medication (risk of hypotension) or cyclosporine (enhanced toxicity). | lld:pubmed |
