| pubmed-article:7859290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7859290 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7859290 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7859290 | pubmed:dateCreated | 1995-3-20 | lld:pubmed |
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| pubmed-article:7859290 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7859290 | pubmed:abstractText | Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 (OBF-1), a novel protein that specifically associates with Oct-1 and Oct-2. Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2, but not those of Oct-4 and Oct-6. The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested. Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site-dependent manner. Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein. | lld:pubmed |
| pubmed-article:7859290 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7859290 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7859290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7859290 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7859290 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:7859290 | pubmed:author | pubmed-author:MatthiasPP | lld:pubmed |
| pubmed-article:7859290 | pubmed:author | pubmed-author:StrubinMM | lld:pubmed |
| pubmed-article:7859290 | pubmed:author | pubmed-author:NewellJ WJW | lld:pubmed |
| pubmed-article:7859290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7859290 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:7859290 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:7859290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7859290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7859290 | pubmed:pagination | 497-506 | lld:pubmed |
| pubmed-article:7859290 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7859290 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7859290 | pubmed:articleTitle | OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. | lld:pubmed |
| pubmed-article:7859290 | pubmed:affiliation | Department of Genetics and Microbiology, University Medical Centre, Geneva, Switzerland. | lld:pubmed |
| pubmed-article:7859290 | pubmed:publicationType | Journal Article | lld:pubmed |
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