| pubmed-article:7843269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0175173 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0206128 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:7843269 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7843269 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7843269 | pubmed:dateCreated | 1995-3-3 | lld:pubmed |
| pubmed-article:7843269 | pubmed:abstractText | Release-regulating gamma-aminobutyric acidB (GABAB) autoreceptors were studied in synaptosomes from fresh specimens of human cerebral cortex. The K+ (12 mM)-evoked overflow of [3H]GABA was inhibited by the GABAB receptor agonists (-)-baclofen (EC50 = 1.48 microM) and 3-aminopropylphosphinic acid (3-APPA; EC50 = 0.034 microM). The effect of 10 microM (-)-baclofen was differentially reduced by the three GABAB receptor antagonists CGP 52432 ([3-[[(3,4-dichlorophenyl)methyl)amino]propyl]-(diethoxymethyl)- phosphinic acid), phaclofen and CGP 35348 (3-aminopropyl-(diethoxymethyl)- phosphinic acid). CGP 52432 was by far the most potent antagonist (IC50 = 0.09 microM). Phaclofen was about 700-fold less potent than CGP 52432 (IC50 = 70.0 microM) while CGP 35348 was ineffective up to 100 microM. The present results suggest that human and rat GABAB neocortical autoreceptors have similar pharmacological characteristics. | lld:pubmed |
| pubmed-article:7843269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7843269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7843269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7843269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7843269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7843269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7843269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7843269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7843269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7843269 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7843269 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7843269 | pubmed:author | pubmed-author:RaiteriMM | lld:pubmed |
| pubmed-article:7843269 | pubmed:author | pubmed-author:BonannoGG | lld:pubmed |
| pubmed-article:7843269 | pubmed:author | pubmed-author:CavazzaniPP | lld:pubmed |
| pubmed-article:7843269 | pubmed:author | pubmed-author:FassioAA | lld:pubmed |
| pubmed-article:7843269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7843269 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:7843269 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:7843269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7843269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7843269 | pubmed:pagination | 311-4 | lld:pubmed |
| pubmed-article:7843269 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7843269 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7843269 | pubmed:articleTitle | Characterization of the GABA autoreceptor in human neocortex as a pharmacological subtype of the GABAB receptor. | lld:pubmed |
| pubmed-article:7843269 | pubmed:affiliation | Institute of Pharmacology and Pharmacognosy, University of Genoa, Italy. | lld:pubmed |
| pubmed-article:7843269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7843269 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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