| pubmed-article:7836405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7836405 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7836405 | lifeskim:mentions | umls-concept:C0059296 | lld:lifeskim |
| pubmed-article:7836405 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:7836405 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:7836405 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7836405 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7836405 | pubmed:dateCreated | 1995-2-24 | lld:pubmed |
| pubmed-article:7836405 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:abstractText | We have isolated and characterized regions important for expression of the mouse Na+/H+ exchanger gene. A 1.1-kilobase fragment upstream of the 5'-untranslated region contains specific DNA motifs characteristic of promoter and enhancer elements including a TATA box, two CAAT boxes, an SP-1 site, a cyclic AMP response element-binding site, and an AP-2-like site. This 1.1-kilobase fragment directs transcription of a luciferase reporter gene in mouse fibroblasts (NIH 3T3) and human Hep G2 cells. Deletion or mutation of an AP-2-like site 100 base pairs from the start site of transcription resulted in loss of most of the reporter plasmid activity. In addition, cotransfection of an AP-2 expression plasmid and the mouse promoter/luciferase plasmid increased the amount of Na+/H+ exchanger-directed transcription in AP-2-deficient Hep G2 cells. Moreover, mobility shift analysis indicated that a putative AP-2-binding site is capable of binding purified AP-2 protein and a specific protein from nuclear extracts of NIH 3T3 cells. The results show that the transcription factor AP-2 may play an important role in regulation of transcription of the mouse Na+/H+ exchanger gene. | lld:pubmed |
| pubmed-article:7836405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7836405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7836405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7836405 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7836405 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7836405 | pubmed:author | pubmed-author:DyckJ RJR | lld:pubmed |
| pubmed-article:7836405 | pubmed:author | pubmed-author:FliegelLL | lld:pubmed |
| pubmed-article:7836405 | pubmed:author | pubmed-author:SilvaN LNL | lld:pubmed |
| pubmed-article:7836405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7836405 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:7836405 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7836405 | pubmed:geneSymbol | NHE-1 | lld:pubmed |
| pubmed-article:7836405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7836405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7836405 | pubmed:pagination | 1375-81 | lld:pubmed |
| pubmed-article:7836405 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
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| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:meshHeading | pubmed-meshheading:7836405-... | lld:pubmed |
| pubmed-article:7836405 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7836405 | pubmed:articleTitle | Activation of the Na+/H+ exchanger gene by the transcription factor AP-2. | lld:pubmed |
| pubmed-article:7836405 | pubmed:affiliation | Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Canada. | lld:pubmed |
| pubmed-article:7836405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7836405 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:20544 | entrezgene:pubmed | pubmed-article:7836405 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7836405 | lld:pubmed |
