| pubmed-article:7834199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7834199 | lifeskim:mentions | umls-concept:C0028429 | lld:lifeskim |
| pubmed-article:7834199 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:7834199 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7834199 | lifeskim:mentions | umls-concept:C0027893 | lld:lifeskim |
| pubmed-article:7834199 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:7834199 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7834199 | pubmed:dateCreated | 1995-3-1 | lld:pubmed |
| pubmed-article:7834199 | pubmed:abstractText | 1. In pentobarbitone anaesthetized dogs, preganglionic stimulation of the superior cervical sympathetic nerve (15V, 1 ms, 10 Hz) induced marked reduction of nasal arterial blood flow, whereas parasympathetic nerve stimulation (5 V, 1 ms, 10-30 Hz) evoked frequency-dependent vasodilatation. 2. Sympathetic nerve stimulation for 3 min at 10 Hz evoked significant (P < 0.05) and prolonged attenuation of the vasodilator response to subsequent parasympathetic stimulation. Pretreatment with phentolamine (0.5 mg kg-1 h-1), propranolol (1 mg kg-1) and atropine (0.5 mg kg-1) reduced the vasoconstrictor effect of sympathetic stimulation by 35 +/- 4% whereas the parasympathetic nerve-evoked vasodilatation was not significantly modified. Atropine-resistant parasympathetic vasodilatation remained significantly attenuated for more than 30 min after non-adrenergic sympathetic nerve-evoked vasoconstriction. 3. Vasodilator effects of exogenous vasoactive intestinal polypeptide and peptide histidine isoleucine and vasoconstrictor effects of exogenous neuropeptide Y (NPY) and the NPY analogue [Leu31, Pro34] NPY (Y1-receptor agonist, 8 nmol kg-1), were not altered by adrenoceptor antagonists and atropine f1p4eas the effects of exogenous noradrenaline and acetylcholine were virtually abolished. Attenuation of parasympathetic-evoked vasodilatation could be mimicked by exogenous NPY (8 nmol kg-1) and the NPY analogue, N-acetyl [Leu28, Leu31] NPY 24-36 (Y2-receptor agonist, 20 nmol kg-1) but not by exogenous Y1-receptor agonist. The Y2-receptor agonist did not show significant vasoconstrictor action. 4. It is concluded that sympathetic nerve stimulation attenuates parasympathetic vasodilatation via NPY release acting on prejunctional Y2 receptors. | lld:pubmed |
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| pubmed-article:7834199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7834199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7834199 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7834199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7834199 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7834199 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7834199 | pubmed:author | pubmed-author:PotterE KEK | lld:pubmed |
| pubmed-article:7834199 | pubmed:author | pubmed-author:LacroixJ SJS | lld:pubmed |
| pubmed-article:7834199 | pubmed:author | pubmed-author:UlmanL GLG | lld:pubmed |
| pubmed-article:7834199 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7834199 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7834199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7834199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7834199 | pubmed:pagination | 479-84 | lld:pubmed |
| pubmed-article:7834199 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7834199 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7834199 | pubmed:articleTitle | Modulation by neuropeptide Y of parasympathetic nerve-evoked nasal vasodilatation via Y2 prejunctional receptor. | lld:pubmed |
| pubmed-article:7834199 | pubmed:affiliation | Prince of Wales Medical Research Institute, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia. | lld:pubmed |
| pubmed-article:7834199 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7834199 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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