| pubmed-article:7823576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0242640 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C2826293 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7823576 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7823576 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7823576 | pubmed:dateCreated | 1995-2-16 | lld:pubmed |
| pubmed-article:7823576 | pubmed:abstractText | Twenty-four fresh tumors of gastric carcinoma were assessed by flow cytometric detection of P-glycoprotein (P-gp) using monoclonal antibody C219. Eight patients were P-gp positive. Differentiated gastric carcinomas contained significantly higher concentrations of P-gp positive. Incidence of P-gp positive was high in advanced stage. In 16 cases estimated chemosensitivity was test assessed by thymidine incorporation assay (TIA). Seven of nine multidrug-resistant cases according to TIA were P-gp positive and all of seven nonmultidrug resistant cases were P-gp negative. Expression of P-gp and multidrug resistance were closely correlated (P < 0.01). Also, in 89 patients with operable gastric carcinoma, the relation between in vitro chemosensitivity test (TIA) and their clinicopathologic features as well as their survival lengths were studied. Thirty-one of 89 specimens from gastric carcinoma patients were multidrug resistant according to TIA. Patients in the multidrug-resistant group had a significantly poorer cumulative survival rate than those who were not multidrug resistant (P < .05). The multivariate analysis showed that multidrug resistance is a useful indicator of prognosis (P < 0.1). We suggest that multidrug-resistant cases or P-gp-positive cases of gastric carcinoma are highly malignant, and these determinations are clinically useful. | lld:pubmed |
| pubmed-article:7823576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7823576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7823576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7823576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7823576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7823576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7823576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7823576 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7823576 | pubmed:issn | 0022-4790 | lld:pubmed |
| pubmed-article:7823576 | pubmed:author | pubmed-author:FujiiHH | lld:pubmed |
| pubmed-article:7823576 | pubmed:author | pubmed-author:TanakaTT | lld:pubmed |
| pubmed-article:7823576 | pubmed:author | pubmed-author:TanigawaNN | lld:pubmed |
| pubmed-article:7823576 | pubmed:author | pubmed-author:MuraokaRR | lld:pubmed |
| pubmed-article:7823576 | pubmed:author | pubmed-author:ShimomatsuyaT... | lld:pubmed |
| pubmed-article:7823576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7823576 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:7823576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7823576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7823576 | pubmed:pagination | 63-9 | lld:pubmed |
| pubmed-article:7823576 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:meshHeading | pubmed-meshheading:7823576-... | lld:pubmed |
| pubmed-article:7823576 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7823576 | pubmed:articleTitle | Clinical significance of multidrug resistance and P-glycoprotein expression in patients with gastric carcinoma. | lld:pubmed |
| pubmed-article:7823576 | pubmed:affiliation | Second Department of Surgery, Fukui Medical School, Japan. | lld:pubmed |
| pubmed-article:7823576 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7823576 | lld:pubmed |
