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pubmed-article:7792529rdf:typepubmed:Citationlld:pubmed
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pubmed-article:7792529pubmed:issue9lld:pubmed
pubmed-article:7792529pubmed:dateCreated1995-7-25lld:pubmed
pubmed-article:7792529pubmed:abstractTextAging and menopause are the two main determinants of osteoporosis, a rarifying osteopathy due to bone loss. Type I osteoporosis observed in post-menopausal women is characterized mainly by trabecular bone loss results from an unbalanced coupling between resorption and formation inducing a thinning of trabeculae and from an increased osteoclast activation resulting in irreversible trabecular perforation. Anti-osteoclastic drugs prevent trabecular and cortical bone loss. Drugs that stimulate osteoblastic proliferation thicken trabecular plates but do not restore the normal trabecular microarchitecture after complete destruction of a large number of trabeculae. In type II osteoporosis, cortical bone loss is favoured by secondary hyperparathyroidism and is responsible for hip fracture. Calcium and vitamin D supplementations decrease the risk of hip fractures by reducing the secondary hyperparathyroidism.lld:pubmed
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pubmed-article:7792529pubmed:statusMEDLINElld:pubmed
pubmed-article:7792529pubmed:monthMaylld:pubmed
pubmed-article:7792529pubmed:issn0035-2640lld:pubmed
pubmed-article:7792529pubmed:authorpubmed-author:MeunierP JPJlld:pubmed
pubmed-article:7792529pubmed:authorpubmed-author:ChavassieuxPPlld:pubmed
pubmed-article:7792529pubmed:issnTypePrintlld:pubmed
pubmed-article:7792529pubmed:day1lld:pubmed
pubmed-article:7792529pubmed:volume45lld:pubmed
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pubmed-article:7792529pubmed:authorsCompleteYlld:pubmed
pubmed-article:7792529pubmed:pagination1083-8lld:pubmed
pubmed-article:7792529pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:7792529pubmed:meshHeadingpubmed-meshheading:7792529-...lld:pubmed
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pubmed-article:7792529pubmed:year1995lld:pubmed
pubmed-article:7792529pubmed:articleTitle[Mechanisms of bone loss in osteoporosis].lld:pubmed
pubmed-article:7792529pubmed:affiliationINSERM unité 403, Faculté Alexis Carrel, Lyon.lld:pubmed
pubmed-article:7792529pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7792529pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:7792529pubmed:publicationTypeReviewlld:pubmed