| pubmed-article:7773443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7773443 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:7773443 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7773443 | pubmed:dateCreated | 1995-7-13 | lld:pubmed |
| pubmed-article:7773443 | pubmed:abstractText | Intracellular electrophysiological recordings in current- and voltage-clamp mode were obtained from dopaminergic neurons of the rat mesencephalon in an in vitro slice preparation. In current-clamp mode, a time-dependent anomalous rectification (TDR) of the membrane was observed in response to hyperpolarizing current pulses. In single-electrode voltage-clamp mode, a slowly developing inward current (Ih) underlying the TDR was studied by hyperpolarizing voltage commands from a holding potential of -50 to -60 mV. Ih started to be activated at approximately -69 mV, was fully activated at -129 to -141 mV, with half-maximal activation at -87 mV, and showed no inactivation with time. The time course of development of Ih followed a single exponential, and its time constant was voltage-dependent. At -81 mV, Ih activated with a time constant of 379 +/- 47.6 ms, whereas at -129 mV Ih activated with a time constant of 65 +/- 2.2 ms. Its estimated reversal potential was -35 +/- 4 mV. Raising the extracellular concentration of K+ from 2.5 to 6.5 and to 12.5 mM increased the amplitude of Ih while reducing the extracellular concentration of Na+ from 153.2 to 27.2 mM caused a reduction in amplitude of Ih. Bath application of caesium (1-5 mM) reversibly reduced or blocked the TDR/Ih. Perfusion of tetrodotoxin (0.5-1 microM), tetraethylammonium (10-20 mM) or barium (0.3-2 mM) did not significantly affect Ih. Ih was also present in cells impaled with CsCl-filled electrodes.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7773443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7773443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7773443 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7773443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7773443 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7773443 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:7773443 | pubmed:author | pubmed-author:BernardiGG | lld:pubmed |
| pubmed-article:7773443 | pubmed:author | pubmed-author:CalabresiPP | lld:pubmed |
| pubmed-article:7773443 | pubmed:author | pubmed-author:StefaniAA | lld:pubmed |
| pubmed-article:7773443 | pubmed:author | pubmed-author:MercuriN BNB | lld:pubmed |
| pubmed-article:7773443 | pubmed:author | pubmed-author:BonciAA | lld:pubmed |
| pubmed-article:7773443 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7773443 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7773443 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:7773443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7773443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7773443 | pubmed:pagination | 462-9 | lld:pubmed |
| pubmed-article:7773443 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:7773443 | pubmed:meshHeading | pubmed-meshheading:7773443-... | lld:pubmed |
| pubmed-article:7773443 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7773443 | pubmed:articleTitle | Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. | lld:pubmed |
| pubmed-article:7773443 | pubmed:affiliation | Clinica Neurologica, University of Tor Vergata-Rome, Italy. | lld:pubmed |
| pubmed-article:7773443 | pubmed:publicationType | Journal Article | lld:pubmed |
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