| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:7755905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7755905 | lifeskim:mentions | umls-concept:C0027763 | lld:lifeskim |
| pubmed-article:7755905 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:7755905 | lifeskim:mentions | umls-concept:C0042567 | lld:lifeskim |
| pubmed-article:7755905 | lifeskim:mentions | umls-concept:C0017082 | lld:lifeskim |
| pubmed-article:7755905 | lifeskim:mentions | umls-concept:C0009807 | lld:lifeskim |
| pubmed-article:7755905 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:7755905 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7755905 | pubmed:abstractText | Glycosphingolipids are uniquely distinguished amongst the glycoconjugates by the apparently systematic structuring of their ceramide-linked carbohydrate moieties. These often highly complex oligosaccharides provide a structural repertoire that may vary considerably according to cell types and animal species. However, as a possible reflection of their specific functional role in the central nervous system, the brain glycosphingolipids of all vertebrates follow the same principles of carbohydrate structuring with only minor variations: the anabolically early addition of sialic acid to lactosylceramide (Gal beta 4Glc beta Cer-->NeuAc alpha 3Gal beta 4Glc beta Cer) in central nervous tissue results in the preferential formation of 'gangliosides', i.e., sialic acid-containing glycosphingolipids. Higher gangliosides result from extensions of sialo-lactosylceramide by addition of nucleotide-activated monosaccharides. In consequence, gangliosides of the vertebrate central nervous system consist of ceramide-linked sialo-oligosaccharides of varying chain length with a ganglio-series core carbohydrate, i.e., GalNAc beta 4Gal beta 3GalNAc beta 4Gal beta 4Glc beta < 0. Substitution by mono-, bis-, or tris-sialo-groups may variably be at the galactoside- and N-acetylgalactosaminide residues in 3- and 6-positions of the ganglio-series oligosaccharides, respectively. Ganglioside, which is derived by sialylation of galactosylceramide, NeuAc alpha 3Gal beta Cer, is a characteristic constituent of glial cells. In nerve tissue, gangliosides of the lacto-(Gal beta(3GlcNAc beta 3Gal beta)n4Glc beta <) and the neolacto-series (Gal beta(4GlcNAc beta 3Gal beta)n4Glc <) are more characteristic of vertebrate peripheral nerves and neuroectoderm-derived tumours. Recent studies using monoclonal antibodies have revealed that various single ganglioside components are specifically distributed in nervous tissues. This finding adds a new dimension to the earlier notion that gangliosides are involved in membrane related phenomena including cell to cell interactions, as well as, the modulation of signalling mechanisms. | lld:pubmed |
| pubmed-article:7755905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7755905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7755905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7755905 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7755905 | pubmed:issn | 0166-4328 | lld:pubmed |
| pubmed-article:7755905 | pubmed:author | pubmed-author:WiegandtHH | lld:pubmed |
| pubmed-article:7755905 | pubmed:issnType | lld:pubmed | |
| pubmed-article:7755905 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:7755905 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:7755905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7755905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7755905 | pubmed:pagination | 85-97 | lld:pubmed |
| pubmed-article:7755905 | pubmed:dateRevised | 2006-3-1 | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:meshHeading | pubmed-meshheading:7755905-... | lld:pubmed |
| pubmed-article:7755905 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7755905 | pubmed:articleTitle | The chemical constitution of gangliosides of the vertebrate nervous system. | lld:pubmed |
| pubmed-article:7755905 | pubmed:affiliation | Physiologisch-Chemisches Institut, Philipps-Universität, Marburg, Germany. | lld:pubmed |
| pubmed-article:7755905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7755905 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7755905 | lld:pubmed |